20.500.12556/DKUM-93283 Primerjava učinkovitosti antiseptične alkoholne raztopine s klorheksidinom in alkoholne raztopine s povidon-jodidom pri pripravi operativnega mesta A comparison of the efficacy of antiseptic alcohol solutions with chlorhexidine and alcohol solutions with povidone-iodine in the preparation of the surgical site Uvod: Učinkovita predoperativna antisepsa kože je ključna za preprečevanje okužb kirurškega mesta, ki so povezane z večjo obolevnostjo in stroški zdravljenja. Kljub pogosti uporabi antiseptikov na osnovi klorheksidina in povidon-jodida ni soglasja glede njihove primerjalne učinkovitosti. Namen zaključnega dela je preučiti in primerjati učinkovitost antiseptičnih alkoholnih raztopin, kot sta klorheksidin in povidon-jodid, pri preprečevanju okužb kirurških ran. Metode: Izveden je bil pregled literature v podatkovnih bazah PubMed, CINAHL Ultimate in ScienceDirect. Vključitveni kriteriji so bili randomizirane kontrolirane raziskave ter sistematični pregledi v angleškem jeziku. Pregled literature je prikazan v PRISMA diagramu. Izvedena je bila kritična ocena analiziranih raziskav, rezultati so prikazani opisno v evalvacijski in sintezni tabeli. Rezultati: V analizo je bilo vključenih osem raziskav. V večini je bila ugotovljena rahla prednost antiseptika s klorheksidinom pri zmanjševanju pogostosti okužb operativnega mesta. Učinkovitost antiseptika je bila odvisna tudi od vrste kirurškega posega, koncentracije pripravka in kliničnega okolja. Razprava in zaključek: Zaradi heterogenosti rezultatov in odsotnosti enotnih primerjalnih pogojev ni mogoče oblikovati univerzalnega priporočila o izbiri antiseptika. Uporaba antiseptika mora biti prilagojena posameznemu kliničnemu primeru. Za oblikovanje trdnejših smernic so potrebne nadaljnje visokokakovostne raziskave. Introduction: Effective preoperative skin antisepsis is crucial for preventing surgical site infections, which are associated with increased morbidity and healthcare costs. Despite the frequent use of antiseptics based on chlorhexidine and povidone-iodine, there is no consensus regarding their comparative effectiveness. The aim of this thesis is to investigate and compare the efficacy of antiseptic alcohol solutions, such as chlorhexidine and povidone-iodine, in preventing surgical wound infections. Methods: A literature review was conducted using databases such as PubMed, CINAHL Ultimate, and ScienceDirect. Inclusion criteria included randomized controlled trials and systematic reviews published in English. The literature review is presented in a PRISMA diagram. A critical evaluation of the analyzed studies was carried out, and the results are presented descriptively in an evaluation and synthesis table. Results: Eight studies were included in the analysis. In most studies, a slight advantage of the chlorhexidine-based antiseptic was found in reducing the incidence of surgical site infections. The effectiveness of the antiseptic also depended on the type of surgical procedure, the concentration of the solution, and the clinical environment. Discussion and Conclusion: Due to the heterogeneity of the results and the lack of uniform comparative conditions, it is not possible to form a universal recommendation regarding the choice of antiseptic. The use of antiseptics must be tailored to the individual clinical case. Further high-quality research is needed to establish more robust guidelines. klorheksidin povidon-jodid okužbe kirurškega mesta predoperativna priprava kože chlorhexidine povidone-iodine surgical site infection preoperative skin preparation true true false [D. Kokot] Slovenski jezik Angleški jezik Magistrsko delo 2025-06-17 18:38:22 2025-08-25 14:53:12 2025-08-26 03:35:33 0000-00-00 00:00:00 2025 0 Maribor 0 0000-00-00 NiDoloceno NiDoloceno NiDoloceno 0000-00-00 0000-00-00 0000-00-00 648.6:725.511.055:617-089(043.2) 246518787 MAG_Kokot_Darko_2025.pdf MAG_Kokot_Darko_2025.pdf 1 B0EA0B1BB0DD0E9C7F2ABF3EAB1F52C2 cfe9834d0618675ab33b9e86894925cd9c5f3e02b085b312a9c433e5aca04694 5a7057a5-81a1-11f0-adee-00155d000105 https://dk.um.si/Dokument.php?lang=slv&id=196201 Fakulteta za zdravstvene vede 0 0 0