20.500.12556/DKUM-94078 CFD simulacija polnjenja vijale s suspenzijo deformabilnih delcev magistrsko delo CFD simulation of vial filling with suspension of deformable particles V magistrskem delu je predstavljena numerična analiza procesa polnjenja farmacevtske vijale s suspenzijo, ki vsebuje enkrat nedeformabilne in drugič deformabilne mikrodelce. Glavni cilj simulacij je bil preučiti dinamiko tokovnega polja ter vpliv polnilnega procesa na gibanje in deformacijo delcev v tekočini. Uporabljena je bila metoda VOF za sledenje proste gladine med zrakom in vodo, dopolnjena z Lagrangevim pristopom za sledenje delcev. Porazdelitev nedeformabilnih ter deformabilnih delcev med in po polnjenju je zelo podobna, prav tako učinek usedanja. Rezultati pokažejo, da polnjenje vijale večinoma ni kritičen del proizvodnega procesa takšnih zdravil, saj so deformacije delcev minimalne. The master's thesis presents a numerical analysis of the process of a pharmaceutical vial filling with a suspension containing non-deformable and deformable microparticles. The main objective of the simulations was to study the flow field dynamics and the effect of the filling process on the motion and deformation of particles in the fluid. The VOF method was used to track the free surface between air and water, supplemented by the Lagrangian approach for particle tracking. The distribution of non-deformable and deformable particles during and after filling is very similar, as is the effect of sedimentation. The results indicate that the vial filling process is generally not a critical stage of the production process for such pharmaceutical products, as particle deformations are minimal. računalniška dinamika tekočin (CFD) VOF metoda Lagrangevo sledenje delcev deformabilni mikrodelci computational fluid dynamics (CFD) VOF method Lagrangian particle tracking deformable microparticles true true false [N. Harl] Slovenski jezik Angleški jezik Magistrsko delo/naloga 2025-07-30 20:25:04 2025-08-22 12:23:56 2025-09-16 03:22:25 0000-00-00 00:00:00 2025 0 Maribor 0 Maribor 1 spletni vir (1 datoteka PDF (XV, 61 f.)) 0000-00-00 NiDoloceno NiDoloceno NiDoloceno 0000-00-00 0000-00-00 0000-00-00 532:519.6(043.2) 248964355 MAG_Harl_Nika_2025.pdf MAG_Harl_Nika_2025.pdf 1 C0F57694BCC303292A7EBD144F4CFC93 c36442eb6f8e019f54830f5d12ca4918dfb27353cf58de67a9c07df55f2f149f 2ef413f5-7ddb-11f0-a14c-00155d000105 https://dk.um.si/Dokument.php?lang=slv&id=195748 Fakulteta za strojništvo 0 0 0