20.500.12556/DKUM-94315 Učinkovitost HIV profilakse pri moških, ki imajo spolne odnose z moškimi Effectiveness of HIV prophylaxis in men who have sex with men Uvod: Okužba z virusom človeške imunske pomanjkljivosti ostaja pomemben javnozdravstveni problem, zlasti pri moških, ki imajo spolne odnose z moškimi. V zadnjem desetletju se, kot učinkovita preventivna strategija, uveljavlja zaščita pred izpostavitvijo virusu. Namen zaključnega dela je raziskati učinkovitost profilakse pri preprečevanju prenosa okužbe z virusom HIV med moškimi, ki imajo spolne odnose z moškimi. Metode: V zaključnem delu smo izvedli pregled znanstvene literature po smernicah PRISMA. Uporabljena je bila opisna metoda z analizo in sintezo 11 raziskav, izbranih na podlagi PIO-pristopa. Članki so bili pridobljeni iz podatkovnih baz PubMed, CINAHL in Web of Science za obdobje 2015–2025. Rezultati: Ugotovitve kažejo, da PrEP pomembno zmanjšuje tveganje za prenos HIV med MSM, pri čemer so stopnje učinkovitosti močno odvisne od adherence, pokritosti in ciljanja visoko rizičnih skupin. Modelne in klinične raziskave potrjujejo tudi sekundarne učinke, kot sta manjša prevalenca in višja starost ob okužbi. Razprava in zaključek: Učinkovitost PrEP-a je potrjena, vendar njena implementacija v slovenskem prostoru zahteva sistemsko podporo, zmanjševanje stigme ter širšo dostopnost. Potrebne so nacionalne smernice in vključitev PrEP-a v javnozdravstvene programe. Introduction: Human immunodeficiency virus infection remains a significant public health problem, particularly among men who have sex with men. Over the past decade, protection against exposure to the virus has emerged as an effective prevention strategy. The purpose of this thesis is to investigate the effectiveness of prophylaxis in preventing HIV transmission among men who have sex with men. Methods: We conducted a literature review in the thesis according to PRISMA guidelines. A descriptive method was used to analyse and synthesise 11 studies selected based on the PIO approach. The articles were obtained from the PubMed, CINAHL, and Web of Science databases from 2015 to 2025. Results: Findings indicate that PrEP significantly reduces the risk of HIV transmission among MSM, with effectiveness rates strongly dependent on adherence, coverage, and targeting of high-risk groups. Modelling and clinical studies also confirm secondary effects such as lower prevalence and older age at infection. Discussion and conclusion: The effectiveness of PrEP has been confirmed, but its implementation in Slovenia requires systemic support, reduced stigma, and wider accessibility. National guidelines and the inclusion of PrEP in public health programs are needed. virus človeške pomanjkljivosti profilaksa preprečevanje prenosa pri moških ki imajo spolne odnose z moškimi human immunodeficiency virus prophylaxis transmission prevention in men who have sex with men true true false [U. Nežmah] Slovenski jezik Angleški jezik Diplomsko delo/naloga 2025-08-13 13:04:51 2025-10-24 14:38:10 2025-12-19 22:26:56 0000-00-00 00:00:00 2025 0 Maribor 0 0000-00-00 NiDoloceno NiDoloceno NiDoloceno 0000-00-00 0000-00-00 0000-00-00 616.98:578.828+316.367.7ž(043.2) 253786371 VS_Nezmah_Urh_2025.pdf VS_Nezmah_Urh_2025.pdf 1 712B108A6B1192E658F2AE3CE20FCF7B 4a09863a3c5842fa472708b276838b509f94013ad433cbb64106d2ec9ed5ee32 a8cbb343-7839-11f0-a457-00155d000105 https://dk.um.si/Dokument.php?lang=slv&id=195228 Fakulteta za zdravstvene vede 0 0 0