20.500.12556/DKUM-94340 Tumor-infiltrating lymphocytes in breast and female genital tract cancers overlooked potential and unexplored frontiers Background: The growing success of cancer immunotherapies has led to significant advances in oncology. However, despite these promising developments, cancer-related mortality remains high for common cancer types such as breast and lower female genital tract cancers. Method: Here, we synthesize recent findings on the prognostic relevance of tumor-infiltrating lymphocytes (TILs) in breast, endometrial, tubo-ovarian, and vulvar cancer. Our analysis covers the relationship between TIL counts and density, immune cell subtype combinations, immunotherapy approaches, and patient outcomes. Results: High TIL infiltration, especially CD8+ T-cells, generally correlates with improved outcomes such as in endometrial cancer (especially the POLE-ultramutated subgroup), invasive breast cancer, and ovarian epithelial tumors. However, in ductal carcinoma in situ (DCIS) of the breast, elevated TIL counts are linked to a worse prognosis. Ethnicity, the tumor microenvironment (TME), and molecular profiles further complicate the prognostic utility of TILs. Conclusions: TIL-based therapies have shown potential in personalized immunotherapy, particularly in recurrent, refractory ovarian cancer. Limited research on rarer gynecologic tumors hinders broader clinical applications. breast cancer endometrial cancer fallopian tube immunotherapy ovarian cancer review tumor microenvironment (TME) tumor‐infiltrating lymphocytes (TILs) vulvar cancer true true true John Wiley & Sons Ltd. Angleški jezik Angleški jezik Znanstveno delo 2025-08-14 03:29:14 2025-08-18 10:31:32 2025-08-19 03:19:51 0000-00-00 00:00:00 2025 0 0 Str. 1-15 Št. 13, št. članka e71023 Letn. 14 2025 0000-00-00 Zaloznikova Objavljeno NiDoloceno 2025-06-23 2025-03-06 2025-06-24 616-006 245427715 10.1002/cam4.71023 2045-7634 RAZ_Skok_Kristijan_2025.pdf RAZ_Skok_Kristijan_2025.pdf 1 8DCD91B4D0143849B3A6BBD2465E886D cf7dd238c06942ab8338045b357f76a92ee2b13bbaa9c19b4de46bcdbfcfbcaa 85b8ef28-7c0d-11f0-b405-00155d000105 https://dk.um.si/Dokument.php?lang=slv&id=195427 https://doi.org/10.1002/cam4.71023 0 a6680fc4-7c0d-11f0-b405-00155d000105 https://dk.um.si/Dokument.php?lang=slv&id=195428 https://onlinelibrary.wiley.com/doi/10.1002/cam4.71023 1 16eadaf0-78ae-11f0-a99e-00155d000105 https://dk.um.si/Dokument.php?lang=slv&id=195292 Medicinska fakulteta 0 0 0