20.500.12556/DKUM-94412 Vpliv probiotikov na kakovost življenja pri bolnikih po operaciji možganov The impact of probiotics on quality of life in patients after brain surgery Uvod: Komunikacijske poti med možgani in mikrobioto omogočajo, da lahko z dodajanjem probiotikov vplivamo na črevesno mikrobioto in posledično na kognitivne sposobnosti. Namen zaključnega dela je bil raziskati vpliv probiotikov na kakovost življenja pri bolnikih po operaciji možganov. Metode: Zaključno delo je temeljilo na pregledu literature z uporabo opisne metode dela. Literaturo smo identificirali iz mednarodnih podatkovnih baz PubMed, ScienceDirect, MEDLINE (EBSCOhost) ter Wiley Online Library. Proces iskanja literature je temeljil na vnaprej opredeljenih vključitvenih in izključitvenih kriterijih ter je prikazan z diagramom poteka v skladu s smernicami PRISMA. Kakovost vključenih raziskav smo ocenili na osnovi hierarhije dokazov. Uporabili smo tematsko analizo in sintezo podatkov. Rezultati: V končno analizo smo vključili 6 ustreznih člankov. Raziskave kažejo, da probiotiki prinašajo le določene koristi za kakovost življenja pri bolnikih po operaciji možganov, kot so krajši čas hospitalizacije, zmanjšanje markerjev vnetja, zmanjšanje tveganja za okužbe, nižja umrljivost ter hitrejše okrevanje črevesne funkcije po operaciji možganov. Razprava in zaključek: Kljub številnim blagodejnim učinkom probiotikov na zdravje naš pregled literature kaže na omejen vpliv probiotikov na kakovost življenja bolnikov po operaciji možganov. Za zanesljivejše zaključke pa so potrebne nadaljnje klinične raziskave z večjim številom udeležencev in standardiziranimi metodami ocenjevanja kakovosti življenja. Introduction: Communication pathways between the brain and the microbiota allow probiotic supplementation to influence the gut microbiota and consequently cognitive abilities. The aim of this thesis was to investigate the impact of probiotics on the quality of life in patients after brain surgery. Methods: The diploma thesis was based on a literature review using a descriptive method of work. The literature was identified from international databases PubMed, ScienceDirect, MEDLINE (EBSCOhost) and Wiley Online Library. The literature search process was based on predefined inclusion and exclusion criteria and presented with a flow diagram according to PRISMA guidelines. The quality of selected studies was based on the hierarchy of evidence. A thematic analysis and data synthesis were conducted. Results: A total of 6 relevant articles were included in the final analysis. The research shows that probiotics bring only some benefits to the quality of life in patients after brain surgery, such as shorter hospitalisation time, reduction of markers of inflammation, reduction of infection risk, lower mortality, and faster recovery of bowel function after brain surgery. Discussion and conclusion: Despite the many health benefits of probiotics, our literature review indicates limited evidence supporting a significant impact of probiotics on quality of life in patients after brain surgery. This highlights the need for further clinical studies involving larger sample sizes and standardized methods for assessing quality of life in order to draw more reliable conclusions. koristne črevesne bakterije kakovost življenja nevrološki bolniki operacija možganov beneficial gut bacteria quality of life neurological patients brain surgery true true false [D. Pukšič] Slovenski jezik Angleški jezik Diplomsko delo/naloga 2025-08-15 10:19:13 2025-10-24 14:00:09 2025-12-19 21:56:46 0000-00-00 00:00:00 2025 0 Maribor 0 0000-00-00 NiDoloceno NiDoloceno NiDoloceno 0000-00-00 0000-00-00 0000-00-00 613.292:316.728:616.831-089(043.2) 252741379 VS_Puksic_Doroteja_2025.pdf VS_Puksic_Doroteja_2025.pdf 1 651E3FEDDB715FF443BE0C9C9F0336DD 0e5e3b5777ae78b2423474f767150e21aafc772b701b43fd0806b7ff1268f040 f9decba1-79b1-11f0-8d64-00155d000105 https://dk.um.si/Dokument.php?lang=slv&id=195369 Fakulteta za zdravstvene vede 0 0 0