20.500.12556/DKUM-95102 Študija prenosa toplote iz police liofilizatorja na viale Study of the heat transfer from the lyophilizer shelf to the vials V diplomskem delu je predstavljena študija prenosa toplote iz police liofilizatorja na viale. Predstavljeno je teoretsko ozadje prenosa toplote ter procesa liofilizacije. S pomočjo numeričnih simulacij smo analizirali prenos toplote na realno ter poenostavljeno geometrijo viale 10R, pri čemer smo z definiranjem toplotnega upora med vialo in polico liofilizatorja poenostavljene geometrije opisali toplotne razmere v realni viali. Rezultate simulacij smo primerjali z eksperimentalno pridobljenimi temperaturnimi poteki ohlajanja destilirane vode v vialah. V diplomskem delu smo ugotovili, da je za validacijo numerične simulacije z eksperimentalnimi rezultati ključno poznavanje masnega toka grelno-hladilnega medija v policah liofilizatorja, ki bistveno vpliva na intenziteto prenosa toplote iz polic liofilizatorja na viale. This thesis presents a study of heat transfer from the shelf of a lyophilizer to the vials. The theoretical background of heat transfer and the lyophilization process is first introduced. Using numerical simulations, we analyzed heat transfer on both the real and simplified geometry of a 10R vial. By defining the thermal resistance between the vial and the shelf of the lyophilizer, the simplified geometry was used to represent the thermal conditions in a real vial. The simulation results were compared with experimentally obtained temperature profiles of distilled water cooling inside the vials. The findings of this thesis show that accurate knowledge of the mass flow rate of the heating–cooling medium in the lyophilizer shelves is crucial for validating the numerical simulations against experimental results, as it significantly influences the intensity of heat transfer from the shelves to the vials. prenos toplote liofilizacija računalniška dinamika tekočin viala heat transfer lyophilization computational fluid dynamics vial true true false [J. Šantl] Slovenski jezik Angleški jezik Diplomsko delo/naloga 2025-09-04 16:33:04 2025-10-02 12:14:27 2025-10-15 13:56:05 0000-00-00 00:00:00 2025 0 Maribor 0 0000-00-00 NiDoloceno NiDoloceno NiDoloceno 0000-00-00 0000-00-00 0000-00-00 536.24(043.2) 21958 UN_Santl_Jakob_2025.pdf UN_Santl_Jakob_2025.pdf 1 E11D459E75797F439F7E13F858CAB039 e3c641c640fd32ce5e08db34641111efb3f1a4f3a2bf7f4478694e52f1a4c0f7 1f19bd76-899d-11f0-8088-00155d000105 https://dk.um.si/Dokument.php?lang=slv&id=197644 Fakulteta za strojništvo 0 0 0