20.500.12556/DKUM-95468 Upravljanje tekočinske bilance pri obsežnih opeklinah Fluid management in extensive burns Uvod: Opekline so poškodbe tkiva, ki jih povzročajo različni dejavniki in pogosto vodijo v obsežno izgubo tekočin. Pri večjih opeklinah je ustrezno nadomeščanje tekočin ključno za preživetje, vendar ostaja optimalna strategija nejasna. Parklandska formula, ki je v klinični praksi najpogosteje uporabljena, je pogosto povezana s prekomernim nadomeščanjem tekočin in zapleti, kot so akutna ledvična odpoved, kompartment sindrom ali večorganska okvara. Namen zaključnega dela je raziskati in analizirati upravljanje tekočinske bilance pri pacientih z obsežnimi opeklinami. Metode: Izveden je bil pregled literature v podatkovnih bazah PubMed, Medline (EBSCOhost), CINAHL (Ultimate), Web of Science in ScienceDirect (Elsevier). Vključene so bile randomizirane kontrolirane raziskave v angleškem jeziku. Pregled literature je prikazan v PRISMA diagramu, kakovost raziskav pa je bila ocenjena s kritično analizo. Rezultati so prikazani v evalvacijski ter sintezni tabeli. Rezultati: V končno analizo so bile vključene 3 analize. Nobena od primerjalnih strategij, kot so uporaba formul za računanje (modificirana Brookova ali Baxterjeva formula), dodatek 5 % albumina ali uporaba HES 130/0,4, ni pokazala prednosti pred standardno kristaloidno terapijo. Kratkoročna 28-dnevna smrtnost je bila nizka in primerljiva med skupinami. Razprava in zaključek: Rezultati kažejo, da izbira formule ali dodatek koloidov ne izboljšata preživetja in ne zmanjšata zapletov pri odraslih z obsežnimi opeklinami, kadar je tekočinska terapija skrbno odmerjena. Ključnega pomena je natančno spremljanje diureze in vitalnih znakov. Introduction: Burn injuries are tissue damages caused by various factors and are often associated with extensive fluid loss. In cases of major burns, appropriate fluid resuscitation is essential for survival; however, the optimal strategy remains uncertain. The Parkland formula, most commonly applied in clinical practice, is frequently associated with fluid overload and coplications such as acute kidney failure, compartment syndrome or multiple organ dysfunction. The purpose of this thesis is to investigate and analyze fluid management in patients with extensive burn injuries. Methods: A literature review was conducted using databases such Pubmed, Medline (EBSCOhost), CINAHL (Ultimate), Web of Science in ScienceDirect (Elsevier). Inclusion criteria included randomised controlled trials in English. The literature review was presented in a PRISMA diagram, while the quality of the included studies was evaluated through critical appraisal. The results are presented in the evaluation and synthesis tables. Results: Three analyses were included in the final synthesis. None of the comparative strategies such as the use of calculation formulas (Modified Brooke or Baxter formula), the addition of 5 % albumin, or the use of HES 130/0,4, demonstrated superiority over standard crystalloid therapy. The short term 28 – day mortality was low and comparable between groups. Discussion and conclusion: The findings indicate that neither the choice of formula nor the addition of colloids improves survival or reduces complications in adults with extensive burn injuries, provided that fluid therapy is carefully titrated. Precise monitoring od urine output and vital signs remains of paramount importance. upravljanje tekočinske bilance nadomeščanje tekočin opekline in izidi fluid management fluid resuscitation burns and outcomes true true false [M. Šadl] Slovenski jezik Angleški jezik Magistrsko delo/naloga 2025-09-19 14:45:10 2025-11-19 12:03:40 2026-02-04 14:58:13 0000-00-00 00:00:00 2025 0 Maribor 0 0000-00-00 NiDoloceno NiDoloceno NiDoloceno 0000-00-00 0000-00-00 0000-00-00 613.3:616-001(043.2) 256989187 MAG_Sadl_Manca_2025.pdf MAG_Sadl_Manca_2025.pdf 1 A0FDD5E0747EC97BB8F48613FE48E593 2f7543bb55aa553f0fe8edb35c24b3bf7e2c4277c4ff037f61b0716158bdc3f2 151cc95c-9557-11f0-8746-00155d000105 https://dk.um.si/Dokument.php?lang=slv&id=198856 Fakulteta za zdravstvene vede 0 0 0