20.500.12556/DKUM-95642 Probiotiki pri zmanjševanju pojavnosti vaginalnih okužb pri ženskah Probiotics in reducing the incidence of vaginal infections in woman Uvod: Vaginalni mikrobiom, kjer prevladujejo laktobacili, predstavlja ključno zaščito pred vaginalnimi okužbami, kot je vulvovaginalna kandidiaza (VVC). Neravnovesje mikrobiote vodi v povečano pojavnost teh okužb. Uporaba probiotikov, zlasti sevov laktobacilov, so obetaven dopolnilni pristop za njihovo preprečevanje in zdravljenje. Namen zaključnega dela je na podlagi pregleda literature analizirati vpliv uživanja probiotikov na zmanjšanje pojavnosti vaginalnih infekcij pri ženskah. Metode: Izvedli smo pregled znanstvene literature v podatkovnih bazah PubMed, SAGE in Cochrane Library. Uporabili smo PRISMA diagram za prikaz izbora virov. Vključili smo sistematične preglede, randomizirane kontrolirane raziskave in kvazieksperimentalno raziskavo. Rezultati: Vključenih je bilo deset raziskav: dve sistematični analizi, sedem randomiziranih s placebom kontroliranih raziskav in ena kvazieksperimentalna. Večina je potrdila, da so probiotiki učinkoviti pri zmanjševanju simptomov VVC ter preprečevanju ponovitev, zlasti v kombinaciji s standardnim antimikotičnim zdravljenjem. Diskusija in zaključek: Uporaba probiotikov, predvsem sevov laktobacilov, kaže potencial pri zdravljenju in preprečevanju VVC, predvsem pri nenosečih ženskah. Učinkovitost je odvisna od seva, načina uporabe in posameznih dejavnikov. Potrebne so dodatne raziskave, zlasti pri nosečnicah, zaradi pomanjkanja raziskav na tem področju. Introduction: The vaginal microbiome, dominated by lactobacilli, plays a key protective role against vaginal infections such as vulvovaginal candidiasis (VVC). An imbalance in the microbiota leads to an increased incidence of these infections. The use of probiotics, particularly lactobacillus strains, represents a promising complementary approach for their prevention and treatment. The aim of this thesis is to analyse the impact of probiotic consumption on the reduction of vaginal infections in women based on a review of the literature. Methods: We conducted a review of scientific literature using the databases PubMed, SAGE, and the Cochrane Library. A PRISMA diagram was used to illustrate the selection process of the sources. We included systematic reviews, randomized controlled trials, and one quasi-experimental study. Results: A total of ten studies were included: two systematic reviews, seven randomized placebo-controlled trials, and one quasi-experimental study. Most of the studies confirmed that probiotics are effective in reducing the symptoms of VVC and preventing recurrences, especially when used in combination with standard antifungal treatment. Discussion and Conclusion: The use of probiotics, particularly lactobacillus strains, shows potential in the treatment and prevention of VVC, especially in non-pregnant women. Effectiveness depends on the specific strain, mode of administration, and individual factors. Further research is needed, particularly in pregnant women, due to the lack of studies in this area. ženska vaginalna okužba probiotiki uporaba vpliv woman vaginal infection probiotics use impact true false false [P. Fras] Slovenski jezik Angleški jezik Diplomsko delo/naloga 2025-10-03 20:30:09 2026-01-12 08:44:21 2026-01-13 03:17:14 0000-00-00 00:00:00 2025 0 Maribor 0 0000-00-00 NiDoloceno NiDoloceno NiDoloceno 0000-00-00 0000-00-00 0000-00-00 613.292:618.15-008.8(043.2) 262122755 VS_Fras_Pija_2025.pdf VS_Fras_Pija_2025.pdf 1 10DBF079F408194739C3D775CD01203D cbf081877a2ff0134d09b700b2b9fdd9847737ae0c107d4d59b4287caa158af8 6114f517-a087-11f0-93a2-00155d000105 https://dk.um.si/Dokument.php?lang=slv&id=199578 Fakulteta za zdravstvene vede 0 0 0