20.500.12556/DKUM-95799 Efficacy of using probiotics with antagonistic activity against pathogens of wound infections an integrative review of literature The skin and its microbiota serve as physical barriers to prevent invasion of pathogens. Skin damage can be a consequence of illness, surgery, and burns. The most effective wound management strategy is to prevent infections, promote healing, and prevent excess scarring. It is well established that probiotics can aid in skin healing by stimulating the production of immune cells, and they also exhibit antagonistic effects against pathogens via competitive exclusion of pathogens. Our aim was to conduct a review of recent literature on the efficacy of using probiotics against pathogens that cause wound infections. In this integrative review, we searched through the literature published in the international following databases: PubMed, ScienceDirect, Web of Science, and Scopus using the search terms “probiotic” AND “wound infection.” During a comprehensive review and critique of the selected research, fourteen in vitro studies, 8 animal studies, and 19 clinical studies were found. Two of these in vitro studies also included animal studies, yielding a total of 39 articles for inclusion in the review. The most commonly used probiotics for all studies were well-known strains of the species Lactobacillus plantarum, Lactobacillus casei, Lactobacillus acidophilus, and Lactobacillus rhamnosus. All in vitro studies showed successful inhibition of chosen skin or wound pathogens by the selected probiotics. Within the animal studies on mice, rats, and rabbits, probiotics showed strong opportunities for counteracting wound infections. Most clinical studies showed slight or statistically significant lower incidence of surgical site infections, foot ulcer infection, or burn infections for patients using probiotics. Several of these studies also indicated a statistically significant wound healing effect for the probiotic groups. This review indicates that exogenous and oral application of probiotics has shown reduction in wound infections, especially when used as an adjuvant to antibiotic therapy, and therefore the potential use of probiotics in this field remains worthy of further studies, perhaps focused more on typical skin inhabitants as next-generation probiotics with high potential. microbiology probiotics medicine wounds infection mikrobiologija probiotiki medicina rane infekcija true true true Hindawi Angleški jezik Slovenski jezik Znanstveno delo 2025-10-23 10:26:01 2026-01-07 11:13:10 2026-01-08 03:19:17 0000-00-00 00:00:00 2019 0 0 str. 1-21 št. članka 7585486 Letn. 2019 2019 0000-00-00 Zaloznikova Objavljeno NiDoloceno 2019-07-22 2019-10-03 2019-12-12 579:616 4341128 10.1155/2019/7585486 2314-6141 2019_Fijan_et_al-probiotics_and_wounds.pdf 2019_Fijan_et_al-probiotics_and_wounds.pdf 1 6891870A2A9961E40BD50CB16CB19F5D 7b2dff7502213005ee6e6dd9846cc9742617bd667c509897e7c1fc7115eff84c 21ec675f-afea-11f0-83c3-00155d000105 https://dk.um.si/Dokument.php?lang=slv&id=200147 2019_Fijan_et_al-probiotics_and_wounds.pdf 2019_Fijan_et_al-probiotics_and_wounds.pdf 1 E6B1ABAF7F36E982D6219E9646A41639 e5092a205f42de1b67849a86bcbf212f4d06173911db50fec243230dea9cafdb 57eea5f9-eaea-11f0-a407-00155d580e02 https://dk.um.si/Dokument.php?lang=slv&id=201786 Fakulteta za zdravstvene vede Medicinska fakulteta 0 0 0