20.500.12556/DKUM-95903 Liposomes: recent progress on nanoparticles production and their usage in medicine Since the discovery of the first nanoparticles, scientists have developed controlled-release drugs, in which nanoparticles play a crucial role as drug carriers. Nanoparticles enable targeted and controlled release, but also face some challenges in their application, production and storage in vivo. The most used nanoparticles for drug encapsulation are liposomes. Liposomes consist of a lipid bilayer membrane that separates the inner hydrophilic/aqueous core from the surrounding environment. In the process known as encapsulation, an active ingredient is added that is either hydrophobic or hydrophilic. Their production is a challenge. Therefore, various production methods have been developed (thin film hydration, reverse phase evaporation, microfluidic methods, etc.) to achieve high encapsulation efficiency, stability and improved drug delivery in vivo. In medical treatment, liposomes are already used as carriers for analgesics, drugs to prevent and treat a variety of diseases (fungal, bacterial, and viral infections) and chemotherapeutics to treat various types of cancer (docetaxel, paclitaxel, doxorubicin, etc.). This article gives an insight into the methods of liposome production, ranging from conventional to more modern techniques with their advantages and disadvantages of the encapsulated substances and their use in medicine. nanoparticles drug delivery liposome preparation methods liposome applications medical substances nanodelci prenos zdravil liposomi medicinske sestavine true false true Elsevier B. V. Angleški jezik Angleški jezik https://www.sciencedirect.com/journal/biomaterials-advances © 2025 The Author(s) Članek v reviji 2025-11-06 13:54:13 2025-11-06 13:54:13 2025-11-07 03:14:59 0000-00-00 00:00:00 2026 0 0 24 str. Vol. 180, [article no.] 214585 Mar. 2026 0000-00-00 Zaloznikova Objavljeno NiDoloceno 2025-07-04 2025-09-18 2025-11-04 620.3 256171779 10.1016/j.bioadv.2025.214585 2772-9508 1-s2.0-S2772950825004121-main.pdf 1-s2.0-S2772950825004121-main.pdf 1 DB151BF3C6A0688A2263D9CCE966F825 4fea6eb873dc80b7be81a724130b4745cd2d642be48503e3385dfaae1fb30c86 de433e91-bb10-11f0-8c37-00155d000105 https://dk.um.si/Dokument.php?lang=slv&id=200457 Fakulteta za elektrotehniko, računalništvo in informatiko 0 0 0