20.500.12556/DKUM-96458 Priprava in lastnosti hidrogelov s polielektrolitskim zamreževanjem polisaharidov za uporabo v biomedicini magistrsko delo Preparation and properties of hydrogels with polyelectrolyte crosslinking of polysaccharides for biomedical applications Hidrogeli predstavljajo skupino polimernih materialov s hidrofilno strukturo, ki jim omogoča zadrževanje velikih količin vode. V raziskavi so bili pripravljeni hidrogeli na osnovi kvarternega hitozana in hialuronske kisline s polielektrolitsko kompleksacijo pri različnih molskih razmerjih in stopnjah ionskega zasenčenja. Hidrogeli so bili pripravljeni brez uporabe toksičnih zamreževalcev. Kemijske in fizikalne lastnosti hidrogelov so bile ovrednotene z Fourierjevo transformacijsko infrardečo spektroskopijo (FTIR), meritvami nabrekanja ter rotacijsko in oscilatorno reološko analizo. Poleg tega je bila preučena sposobnost inkorporacije amoksicilina med dializo. Rezultati kažejo, da sestava hidrogelov pomembno vpliva na njihove lastnosti ter odpirajo možnosti za njihovo nadaljnjo uporabo v različnih biomedicinskih aplikacijah. Hydrogels represent a group of polymeric materials with a hydrophilic structure capable of retaining large amounts of water. In this study, hydrogels based on quaternized chitosan and hyaluronic acid were prepared by polyelectrolyte complexation at different molar ratios and degrees of ionic screening. The hydrogels were synthesised without the use of toxic crosslinking agents. Their chemical and physical properties were evaluated using Fourier-transform infrared spectroscopy (FTIR), swelling measurements, and rotational and oscillatory rheological analysis. In addition, the ability to incorporate amoxicillin into the hydrogel network was investigated during dialysis. The results indicate that the composition of the hydrogels significantly influences their properties and highlights their potential for further application in various biomedical fields. hidrogeli kvarterni hitozan hialuronska kislina polielektrolitska kompleksacija reološke lastnosti biomedicinske aplikacije hydrogels quaternary chitosan hyaluronic acid polyeletrolyte complexation rheological properties biomedical applications true true false [K. Kapetanović] Slovenski jezik Angleški jezik Magistrsko delo/naloga 2026-01-12 13:28:35 2026-02-13 08:16:32 2026-03-14 03:13:05 0000-00-00 00:00:00 2026 0 Maribor 0 Maribor 1 spletni vir (1 datoteka PDF (XIII, 85 f.)) 0000-00-00 NiDoloceno NiDoloceno NiDoloceno 0000-00-00 0000-00-00 0000-00-00 544.773.432:[606:61](043.2) 271527939 MAG_Kapetanovic_Kenan_2026.pdf MAG_Kapetanovic_Kenan_2026.pdf 1 FE172B56F0B35CF225EA77C257F94966 8d94d465c8354bad57ccd17a4543f256fe9b6f54f96725df1f8de277e161ace3 b6e27e7e-08ab-11f1-8973-00155d00019a https://dk.um.si/Dokument.php?lang=slv&id=203291 Fakulteta za strojništvo 0 0 0