20.500.12556/DKUM-96674 Načrtovanje separacijskih alternativ za rekonstrukcijo procesa koncentriranja farmacevtske učinkovine magistrsko delo Design of separation alternatives for the reconstruction of the active pharmaceutical ingredient concentration process V magistrskem delu smo obravnavali rekonstrukcijo procesa koncentriranja aktivne farmacevtske učinkovine iz raztopine etilacetata z vsebnostjo vode. Obstoječi industrijski proces, ki vključuje destilacijsko kolono in tankoslojni izparilnik, predstavlja omejitev z vidika povečevanja proizvodne kapacitete in energijske učinkovitosti. Z uporabo programskega paketa Aspen Plus smo razvili simulacijski model obstoječega procesa in ga validirali z industrijskimi podatki. Rezultati so pokazali, da iz 5221,5 kg/h napajalne raztopine pridobimo 590,5 kg/h koncentrata z masno koncentracijo aktivne farmacevtske učinkovine 64,6 g/L ter 4631 kg/h regeneriranega topila. Analiza je pokazala, da je za obstoječi proces potrebnih približno 586 kW vročega in 654 kW mrzlega pogonskega sredstva. Pri tem moramo poudariti, da izparevanje poteka pri nizkih temperaturah, ugodnih z vidika termične stabilnosti učinkovine. V nadaljevanju smo analizirali dvostopenjsko izparevanje in razpenjanje kot alternativni rešitvi. Dvostopenjsko izparevanje omogoča enako proizvodno kapaciteto ob več kot 50 % nižji porabi vročega in mrzlega pogonskega sredstva, vendar povzroči večjo vsebnost vode v koncentratu. Razpenjanje napajalne raztopine omogoča do 10 % povečanje proizvodne kapacitete in zvišanje koncentracije učinkovine do 71,5 g/L. Magistrsko delo predstavlja uporabno osnovo za nadaljnjo optimizacijo procesa koncentriranja in podporo odločanju pri načrtovanju separacijskih procesov v farmacevtski industriji. In this master’s thesis, the reconstruction of an active pharmaceutical ingredient concentration process from an ethyl acetate solution containing water was investigated. The existing industrial process, which consists of a distillation column and a thin-film evaporator, represents a limitation in terms of increasing production capacity and improving energy efficiency. A simulation model of the existing process was developed using the Aspen Plus software package and validated against industrial data. The results showed that from 5221,5 kg/h of feed solution, 590,5 kg/h of concentrate with an active pharmaceutical ingredient concentration of 64,6 g/L is obtained, along with 4631 kg/h of regenerated solvent. Further analysis showed that the existing process requires approximately 586 kW of hot 654 kW of cold utility. It is important to note that evaporation takes place at relatively low temperatures, which is favorable in terms of the thermal stability of the active ingredient. Furthermore, two-stage evaporation and flash evaporation were analyzed as alternative solutions. Two-stage evaporation enables the same production capacity with more than 50 % lower consumption of hot and cold utilities, but results in a higher water content in the concentrate. Flash evaporation of the feed solution allows up to a 10 % increase in production capacity and an increase in the active ingredient concentration to values as high as 71,5 g/L. This master’s thesis provides a useful basis for further optimization of concentration processes and supports decision-making in the design of separation processes in the pharmaceutical industry. koncentriranje farmacevtske učinkovine simulacija procesov načrtovanje procesov razpenjanje izparevanje destilacija concentration of active pharmaceutical ingredient process simulation process design flash evaporation distillation true true false [R. Goričanec] Slovenski jezik Angleški jezik Magistrsko delo/naloga 2026-01-22 20:15:53 2026-03-05 12:58:01 2026-03-25 03:13:42 0000-00-00 00:00:00 2026 0 Maribor 0 Maribor 1 spletni vir (1 datoteka PDF (IX, 45 str.)) 0000-00-00 NiDoloceno NiDoloceno NiDoloceno 0000-00-00 0000-00-00 0000-00-00 2029-02-18 66.011:66.063.94(043.2) 272739331 MAG_Goricanec_Rafael_2026.pdf MAG_Goricanec_Rafael_2026.pdf 1 269EC492C088E055E5033416B5203C96 c0f0cb3856fe9fad346356245c3bcfab65090bbd7a2472bfa776215eecb5e69e 432bfa75-186a-11f1-b8bb-00155d580e1a https://dk.um.si/Dokument.php?lang=slv&id=204277 Fakulteta za kemijo in kemijsko tehnologijo 0 0 0