20.500.12556/DKUM-96969 Učinkovite intervencije za preprečevanje okužb z respiratornim sincicijskim virusom pri otrocih: pregled literature Effective interventions for prevention of respiratory syncytial virus infections in children: literature review Uvod: RSV je zelo nalezljiv sezonski virus, ki povzroča okužbe dihal, zlati pri dojenčkih, prezgodaj rojenih otrocih in imunokompromitiranih osebah, zaradi česar predstavlja pomembno zdravstveno in ekonomsko breme zaradi pogostih hospitalizacij. Metode: Izvedli smo pregled literature, pridobljene z vnaprej določeno iskalno strategijo v podatkovnih bazah PubMed, CINAHL Ultimate in Cochrane Library. Vključene raziskave smo razvrstili glede na hierarhijo dokazov in ocenili moč dokazov. Rezultati: Od pridobljenih 428 raziskav je bilo za končno analizo in sintezo člankov vključenih devet člankov. S pomočjo vsebinske analize smo oblikovali kategorijo »Učinkovite intervencije za preprečevanje okužb z RSV pri otrocih« in dve podkategoriji »Učinkovitost in varnost cepljenja mater za preprečevanje okužb z RSV pri otrocih« ter »Učinkovitost in varnost monoklonskih protiteles za preprečevanje okužb z RSV pri otrocih«. Razprava in zaključek: Cepljenje nosečnic proti RSV ter uporaba monoklonskih protiteles pri otrocih so učinkovite in varne strategije za zmanjšanje okužb spodnjih dihalnih poti, hospitalizacij in drugih zapletov pri dojenčkih in otrocih. Kljub obetavnim rezultatom so potrebne nadaljnje raziskave glede dolgoročne varnosti, vpliva na prezgodnji porod in vloge socialnih determinant zdravja. Introduction: RSV is a highly contagious seasonal virus that causes respiratory infections, particularly in infants, premature babies, and immunocompromised individuals. As a result, it represents a significant health and economic burden due to frequent hospitalizations. Methods: We conducted a literature review using a predetermined search strategy in the PubMed, CINAHL Ultimate, and Cochrane Library databases. We classified the included studies according to the hierarchy of evidence and assessed the strength of the evidence. Results: Of the 428 studies obtained, 9 articles were included in the final analysis and synthesis of articles. Using content analysis, we formed the category "Effective interventions for the prevention of RSV infections in children" and two subcategories "Effectiveness and safety of maternal vaccination for the prevention of RSV infections in children" and "Effectiveness and safety of monoclonal antibodies for the prevention of RSV infections in children". Discussion and conclusion: Vaccination of pregnant women against RSV and the use of monoclonal antibodies in children are effective and safe strategies for reducing lower respiratory tract infections, hospitalizations, and other complications in infants and children. Despite promising results, further research is needed on long-term safety, the impact on preterm birth, and the role of social determinants of health. respiratorni sincicijski virus preprečevanje otroci učinkoviti ukrepi respiratory syncytial virus prevention children effective interventions true false false [S. Kranjec] Slovenski jezik Angleški jezik Magistrsko delo/naloga 2026-02-07 10:12:46 2026-04-15 18:47:17 2026-04-16 03:08:09 0000-00-00 00:00:00 2026 0 Maribor 0 0000-00-00 NiDoloceno NiDoloceno NiDoloceno 0000-00-00 0000-00-00 0000-00-00 616.2+616.9-053.2(043.2) 274214147 MAG_Kranjec_Sanela_2026.pdf MAG_Kranjec_Sanela_2026.pdf 1 7138EDE98B139A1D95F4620AE800CCC3 2cbbf01d9005a4bd3cabfdec46214180f123c047c506b84f5d001c60f4ed3f5b 49361966-0407-11f1-bdb2-00155d00019a https://dk.um.si/Dokument.php?lang=slv&id=203126 Fakulteta za zdravstvene vede 0 0 0