20.500.12556/DKUM-97049 Symmetry-induced maximum entropy production in enzyme kinetics a noether-type mechanism We investigate the maximum entropy production principle (MEPP) in a minimal two-state enzymatic cycle at a nonequilibrium steady state. Using master-equation kinetics, we show that maximal entropy production arises not by explicit extremization but from internal kinetic constraints together with statistically symmetric occupancy of enzyme states. Under these conditions, the Briggs-Haldane steady-state flux equals the structural upper limit set by the catalytic scheme, while the total thermodynamic force is a constant determined solely by intrinsic unimolecular rates. At the microscopic level, a uniform distribution over configurations admits a Lie group of infinitesimal rotations that leave the probability distribution, flux, and force invariant; hence the entropy-production functional is invariant. This yields a Noether-type interpretation of MEPP: maximal entropy production is a structural invariant of an internally organized enzymatic cycle, rather than an externally imposed variational optimum. nonequilibrium steady state entropy production Shannon entropy enzyme kinetics noether-type symmetry neravnovesno stacionarno stanje produkcija entropije Shannonova entropija kinetika encimov true false true Angleški jezik Slovenski jezik Znanstveno delo 2026-02-13 11:08:46 2026-02-13 11:08:46 2026-02-14 03:11:46 0000-00-00 00:00:00 2026 0 0 12 str. št. članka 131366 Letn. 686 2026 0000-00-00 Zaloznikova Objavljeno NiDoloceno 0000-00-00 0000-00-00 2026-02-09 536.7:530.145:577.152 268368131 10.1016/j.physa.2026.131366 0378-4371 RAZ_Dobovisek_Andrej_2026.htm RAZ_Dobovisek_Andrej_2026.htm 1 76F0DB4F3A17CBBC8DEC8979BFD37460 981bed201a417464b4e6073389cee57dfe6dfffba4e74ae092222ba21792961f 622792b3-08c4-11f1-8973-00155d00019a https://dk.um.si/Dokument.php?lang=slv&id=203319 https://doi.org/10.1016/j.physa.2026.131366 0 703ab748-08c4-11f1-8973-00155d00019a https://dk.um.si/Dokument.php?lang=slv&id=203320 Fakulteta za naravoslovje in matematiko Fakulteta za zdravstvene vede Medicinska fakulteta 0 0 0