20.500.12556/DKUM-97344 Sinteza encima ß-glukozidaze v semenih transgenega riža za nadomestno zdravljenje dedne Gaucherjeve bolezni The Synthesis of the ß-Glucosidase Enzyme in the Transgenic Rice Seeds for Replacement Therapy of the Heritable Gaucher Disease Pridobivanje aktivnih sestavin za zdravila, predvsem cepiva s transgenimi rastlinami se je začelo pred 25 leti. Zaradi določenih prednosti sinteze učinkovin s transgenimi rastlinami, v primerjavi z obstoječim pridobivanjem, se vse bolj uveljavljajo optimizirani transformacijski in ekspresijski sistemi ter njihova uporaba. Do sedaj je bilo v ospredju pridobivanje učinkovin za preventivo in zdravljenje številnih nalezljivih človeških in živalskih bolezni. V zadnjem obdobju je vse več primerov pridobivanja rekombinantnih proteinov za zdravljenje avtoimunskih in genetskih obolenj. Med temi je tudi zelo redka Gaucherjeva bolezen, pomanjkanje encima glukocerebrozidaze, ki jo lahko zdravimo z nadomestnim encimom β-glukozidazo. Transgeni riž uspešno sintetizira in nalaga β-glukozidazo v endosperm v obdobju formiranja in zorenja semen. Production of active ingredients for pharmaceuticals, especially vaccines with transgenic crops, began 25 years ago. Due to certain advantages of the synthesis of active transgenic crops ingredients, in comparison with the current production, the optimized transformation expression systems and their application are gaining ground. Until now, the focus has been on sourcing agents for preventing and treating a variety of infectious human and animal diseases. In recent years, there is an increasing number of cases including the acquiring of recombinant proteins for the treatment of autoimmune and genetic diseases, including the very rare Gaucher disease (lack an enzyme glucocerebrosidase), which can be treated with replacement enzyme β-glucosidase. Transgenic rice successfully synthesized and imposes β-glucosidase in the endosperm during the period of formation and maturation of seeds. transgeni riž ß-glukozidaza Gaucherjeva bolezen sproščanje v okolje tveganje zakonodaja transgenic rice ß-glucosidase Gaucher disease reelase into the environment risk legislation true false true Univerza v Mariboru, Univerzitetna založba Slovenski jezik Angleški jezik Znanstveno delo 2026-03-02 09:08:37 2026-03-02 09:08:38 2026-04-09 14:11:02 0000-00-00 00:00:00 2016 0 Maribor 0 9 št.1/2 Letn.6 nov. 2016 0000-00-00 Zaloznikova Objavljeno NiDoloceno 0000-00-00 0000-00-00 2016-11-01 604 14717491 10.18690/analipazu.6.1-2.20-28.2016 2820-364X Sinteza_encima-Luthar-2016.pdf Sinteza_encima-Luthar-2016.pdf 1 6135FD800E52B05621A19AB59367CD69 0e4e8b09f678577975dd49dcd41f8c0d0770a8b25fc571bca09655ee15e9b82e 569008c1-160f-11f1-a17c-00155d580e1a https://dk.um.si/Dokument.php?lang=slv&id=204073 https://journals.um.si/index.php/anali-pazu/article/view/1983 0 0a6eceb5-160f-11f1-a17c-00155d580e1a https://dk.um.si/Dokument.php?lang=slv&id=204071 Univerzitetna založba Univerze v Mariboru Anali PAZU 0 0 0