20.500.12556/DKUM-97521 Analiza ostankov farmacevtskih učinkovin v pitni in bolnišnični odpadni vodi magistrsko delo Analysis of pharmaceutical residues in drinking and hospital waste water Magistrsko delo obravnava prisotnost izbranih aktivnih farmacevtskih učinkovin (API) v pitni in bolnišnični odpadni vodi rehabilitacijske bolnišnice v Avstriji ter splošne bolnišnice v Sloveniji. Namen dela je preučiti morebitna preseganja koncentracij API glede na razpoložljive smernice in priporočene mejne vrednosti za pitno in podzemno vodo, analizirati vpliv zimskega obdobja na pojavnost API v vodi ter preveriti povezavo med količino izdanih zdravil v slovenski bolnišnici in izmerjenimi koncentracijami v odpadni vodi. Izvedli smo vzorčenje pitne in odpadne vode v obeh bolnišnicah v zimskem obdobju ter kemijsko analizo izbranih API. Rezultate za slovensko bolnišnico smo primerjali s podatki o porabi zdravil v splošni bolnišnici ter obstoječo znanstveno literaturo. Rezultati kažejo, da analizirane API v pitni vodi niso presegle priporočenih mejnih vrednosti 0,004 µg/L oziroma 0,002 µg/L za določene API, skladno s priporočili WHO (2012). V odpadni vodi so bile izmerjene koncentracije API bistveno višje od upoštevane mejne vrednosti 0,4–0,5 µg/L, predvsem pri paracetamolu, naproksenu, kofeinu in ciprofloksacinu. Ugotovili smo močno povezavo med količino izdanih zdravil in koncentracijami v odpadni vodi (R^2=0,9332). Pri nekaterih API rezultati nakazujejo možnost akumulacije ter slabšo biorazgradnjo v obstoječih čistilnih sistemih. Rezultati analiz pitne vode potrjujejo ustrezno kakovost pitne vode. Rezultati analiz odpadne vode predstavljajo pomemben prispevek k oblikovanju strategij monitoringa mikroonesnažil. Glede na zaznane koncentracije antibiotikov je smiselno preučiti možnosti nadgradnje obstoječih sistemov čiščenja z namenom povečanja učinkovitosti njihove odstranitve. This master's thesis investigates the occurrence of selected active pharmaceutical ingredients (APIs) in drinking water and hospital wastewater from a rehabilitation hospital in Austria and a general hospital in Slovenia. The aim of the study was to assess potential exceedances of API concentrations in relation to available guidelines and recommended limit values for drinking and groundwater, to analyse the influence of the winter period on the occurrence of APIs in water, and to evaluate the relationship between the quantity of prescribed medicines in the Slovenian hospital and the measured concentrations in wastewater. Drinking water and wastewater samples were collected in both hospitals during the winter period, followed by chemical analysis of selected APIs. Results for the Slovenian hospital were compared with pharmaceutical consumption data from the general hospital and relevant scientific literature. The results indicate that the analysed APIs in drinking water did not exceed the recommended limit values of 0.004 µg/L and 0.002 µg/L for specific APIs, in accordance with WHO (2012) recommendations. In wastewater, API concentrations were significantly higher than the applied reference value of 0.4–0.5 µg/L, particularly for paracetamol, naproxen, caffeine, and ciprofloxacin. A strong correlation was observed between the quantity of prescribed medicines and their concentrations in wastewater (R² = 0.9332). For certain APIs, the results suggest possible accumulation and limited biodegradation in existing wastewater treatment systems. The drinking water results confirm appropriate water quality. The wastewater findings provide an important contribution to the development of monitoring strategies for micropollutants. Considering the detected concentrations of antibiotics, further evaluation of upgrading existing treatment systems to enhance removal efficiency is recommended. Aktivne farmacevtske učinkovine (API) bolnišnična odpadna voda pitna voda biorazgradnja farmacevtsko onesnaženje Active pharmaceutical ingredients (APIs) hospital wastewater drinking water biodegradation pharmaceutical contamination true true false [L. Kaisersberger] Slovenski jezik Angleški jezik Magistrsko delo/naloga 2026-03-15 19:01:30 2026-05-07 08:50:16 2026-05-23 03:05:42 0000-00-00 00:00:00 2026 0 Maribor 0 Maribor 1 spletni vir (1 datoteka PDF (XII, 51 str.)) 0000-00-00 NiDoloceno NiDoloceno NiDoloceno 0000-00-00 0000-00-00 0000-00-00 543.3+628.312.5(043.2) 279043331 MAG_Kaisersberger_Lea_2026.pdf MAG_Kaisersberger_Lea_2026.pdf 1 13440C50588D5E79DA51A70926B5C2BE 70bcaefa058b00509af9cce760fa725bae408092fc28af7a0e2fe3657450c3e7 6aef7e41-4960-11f1-baa1-00155d0001a1 https://dk.um.si/Dokument.php?lang=slv&id=205844 Fakulteta za kemijo in kemijsko tehnologijo 0 0 0