20.500.12556/DKUM-97549 Sex differences in motor unit behavior in patients with parkinson's disease The aim of this study was to determine whether there are sex differences in motor unit firing behavior in patients with Parkinson'sdisease. Twenty-seven patients with Parkinson's disease (females = 14 [age = 71.1 ± 6.8], males = 13 [age = 69.2 ± 10.3], UnifiedParkinson's Disease Rating Scale Part III score; females = 10.8 ± 4.8, males = 11.4 ± 1.4) performed a contraction at 30% of themaximal voluntary contraction. For each participant, motor unit spike trains were decomposed from high- density surface elec-tromyography data recorded from bilateral vastus lateralis muscles via blind source separation algorithms. In addition to themean discharge rates, persistent inward currents were estimated via a paired motor unit analysis. Females presented signifi-cantly greater laterality of discharge rate (p = 0.001) and persistent inward currents (p = 0.0121) than males. A significant corre-lation was observed between the discharge rate and the recruitment threshold on the bilateral side of males and the less-affectedside of females but not on the more-affected side of females. These findings indicate that sex differences in motor unit behaviorexist in Parkinson's disease patients. Motor unit behavior may be a sensitive and quantitative evaluation tool to highlight differ-ences in disease presentation between males and females. electromyography Parkinson's diseas sex difference motor unit Parkinsonova bolezen elektromiografija motorika true false true Wiley Angleški jezik Slovenski jezik https://onlinelibrary.wiley.com/journal/14609568 © 2025 The Author(s) Članek v reviji 2026-03-18 16:14:16 2026-03-18 16:14:16 2026-03-19 04:02:30 0000-00-00 00:00:00 2025 0 0 12 str. iss. 1 Vol. 62 Jun. 2025 0000-00-00 Zaloznikova Objavljeno NiDoloceno 2025-03-30 2025-06-25 2025-07-07 616.8:004.5 271806723 10.1111/ejn.70191 1460-9568 Eur_J_of_Neuroscience_-_2025_-_Nishikawa_-_Sex_Differences_in_Motor_Unit_Behavior_in_Patients_With_Parkinson_s_Disease.pdf Eur_J_of_Neuroscience_-_2025_-_Nishikawa_-_Sex_Differences_in_Motor_Unit_Behavior_in_Patients_With_Parkinson_s_Disease.pdf 1 7CF210E147487E0285975DA66534CED1 c8da22974307ab524cbd38bbd9f24ca62ae9412f1dcf854aba635514ce50b37a 607c61dd-22dd-11f1-b351-00155d0001a1 https://dk.um.si/Dokument.php?lang=slv&id=204633 Fakulteta za elektrotehniko, računalništvo in informatiko 0 0 0