20.500.12556/DKUM-97626 Vpliv probiotikov na sindrom razdražljivega črevesja pri odraslih The impact of probiotics on irritable bowel syndrome in adults Uvod: Za sindrom razdražljivega črevesja je značilna prisotnost različnih gastrointestinalnih simptomov. Bolniki poročajo tudi o občutku izgube svobode, poudarjajo nepredvidljivost svojih simptomov ter občutijo stigmatizacijo. Probiotiki so živi mikroorganizmi, ki pozitivno vplivajo na zdravje, kadar jih apliciramo v zadostnem številu. Pomembni lastnosti probiotikov sta protimikrobno delovanje in sposobnost vzdrževanja ravnovesja črevesne mikrobiote. Namen diplomskega dela je raziskati vpliv probiotikov na lajšanje simptomov pri odraslih bolnikih s sindromom razdražljivega črevesja. Metode: V okviru svojega dela smo uporabili deskriptivno metodo, ki je služila kot osnova za pregled literature. Iskanje literature je potekalo po tujih podatkovnih bazah PubMed, ScienceDirect, Cochrane Library ter dodatno v iskalniku Google Učenjak. Potek iskanja smo prikazali s pomočjo diagrama PRISMA. Rezultati: Rezultati pregleda literature so pokazali, da imajo probiotiki pomemben potencial pri lajšanju sindroma razdražljivega črevesja. Večina študij poroča o zmanjšanju bolečin v trebuhu, napihnjenosti in izboljšanju konsistence blata po uporabi probiotikov. Ugotovljeno je bilo, da so kombinacije različnih sevov, zlasti iz rodov Lactobacillus in Bifidobacterium, pogosto učinkovitejše od uporabe posameznih sevov. Razprava in Zaključek: Na podlagi pregleda literature o učinkih probiotikov na sindrom razdražljivega črevesja smo ugotovili, da imajo probiotiki koristen učinek na črevesno mikrobioto, zmanjšujejo vnetje in uravnavajo komunikacijo vzdolž osi črevesna mikrobiota‒možgani. Uporaba probiotikov lahko pomaga zmanjšati pogostost in intenzivnost simptomov ter izboljšati kakovost življenja pri odraslih s sindromom razdražljivega črevesja. Vendar so učinki odvisni od vrste seva in individualnega odziva bolnikov, zato so za boljše razumevanje njihovega delovanja potrebne dodatne kakovostne, dolgoročne študije. Introduction: Irritable bowel syndrome is characterized by a variety of gastrointestinal symptoms. Patients also report a feeling of loss of freedom, emphasize the unpredictability of their symptoms, and experience stigmatization. Probiotics are live microorganisms that, when consumed in adequate amounts, confer a health benefit to the host. Important traits of probiotics include as antimicrobial activity and the ability to maintain the balance of the gut microbiota. The aim of this thesis was to investigate the impact of probiotics on alleviating symptoms in adult patients with irritable bowel syndrome. Methods: In this study, we employed a descriptive method, which served as the basis for a literature review. The literature search was be conducted in international databases, specifically PubMed, ScienceDirect, and Cochrane Library, as well as in the Google Scholar search engine. The search process is presented using a PRISMA diagram. Results: The results of the literature review indicated that probiotics have significant potential in alleviating irritable bowel syndrome. Most studies reported a reduction in abdominal pain and bloating, as well as an improvement in stool consistency following probiotic use. It was found that combinations of different strains—particularly those belonging to the genera Lactobacillus and Bifidobacterium—are often more effective than the use of single-strain probiotics. Discussion and Conclusion: Based on our review of the literature on the effects of probiotics in irritable bowel syndrome, we found that probiotics exert beneficial effects on the gut microbiota, reduce inflammation, and regulate communication along the gut microbiota–brain axis. The use of probiotics may help decrease the frequency and intensity of symptoms and improve the quality of life in adults with irritable bowel syndrome. However, the effects depend on the specific probiotic strain and individual patient response. Therefore, additional high-quality, long-term studies are needed to better understand their mechanisms of action and clinical efficacy. sindrom razdražljivega črevesja probiotiki odrasli irritable bowel sindrom probiotics adults true false false [A. Sutiahina] Slovenski jezik Angleški jezik Diplomsko delo/naloga 2026-03-25 20:48:39 2026-07-01 13:01:01 2026-07-02 03:07:32 0000-00-00 00:00:00 2026 0 Maribor 0 0000-00-00 NiDoloceno NiDoloceno NiDoloceno 0000-00-00 0000-00-00 0000-00-00 616.34-053.8:613.292(043.2) 280872451 VS_Sutiahina_Anastasiia_2026.pdf VS_Sutiahina_Anastasiia_2026.pdf 1 6BF2B2BE866EF5FF0ED29250B3636EFA 73ea196a6c6c968a943334fefb3be796cc3283a3706e2bd895467d23e3312a90 f6277797-290c-11f1-a0a6-00155d0001a1 https://dk.um.si/Dokument.php?lang=slv&id=204818 Fakulteta za zdravstvene vede 0 0 0