20.500.12556/DKUM-97771 Potential health benefits of probiotic strains of Clostridium butyricum Clostridium butyricum is a well-known Gram-positive, spore-forming, obligate anaerobic, and butyrate-producing bacterium with a few species of next-generation probiotic strains. By far, the most well-known strain is Clostridium butyricum CBM588 (also known as MIYAIRI 588). This strain has gained significant attention for its therapeutic potential across a variety of human health conditions. Preclinical studies have shown its ability to stabilize gut microbiota, enhance short-chain fatty acid (SCFA) production, and modulate immune responses, which contribute to its therapeutic effects in conditions such as ulcerative colitis, allergies, and cancer. We examined 28 interventional clinical trials and 7 observational studies investigating the effect of Clostridium butyricum strains. These studies have supported the findings of preclinical trials and demonstrated symptom improvement and immune modulation in diverse conditions. Clostridium butyricum CBM588 has shown efficacy in managing gastrointestinal diseases, such as acute gastroenteritis and inflammatory bowel disease, and has also proven beneficial in immune modulation, as evidenced by its positive effects in allergic rhinitis and cancer immunotherapy. Additionally, CBM588 has been reported to have a favorable safety and tolerability profile in various patient populations, including children, adults, and critically ill patients. Despite these promising results, clinical studies face limitations such as small sample sizes, varied protocols, and short study durations. Future well-designed, large-scale trials are necessary to further validate the long-term safety and efficacy of Clostridium butyricum in clinical practice. Clostridium butyricum spore-forming bacteria probiotics health benefits Clostridium butyricum sporogene bakterije probiotiki zdravstvene koristi true true true MDPI Angleški jezik Slovenski jezik Neznano 2026-04-12 14:04:11 2026-04-13 10:06:05 2026-07-09 12:53:03 0000-00-00 00:00:00 2026 0 0 31 str. št. 4, št. članka 53 Letn. 6 2026 0000-00-00 Zaloznikova Objavljeno NiDoloceno 2026-04-01 2026-04-04 2026-04-08 613:613.292:579.852 274733059 10.3390/applmicrobiol6040053 2673-8007 2026-applmicrobiol-Cl_butyricum.pdf 2026-applmicrobiol-Cl_butyricum.pdf 1 A52929AFF35D111DFB85EFB22B249273 68fac90ae1ea625a2d430f9768f9819d46259e5abf5a1f9ebd78f83e7ac7aadd d5f245ae-3667-11f1-a3c3-00155d0001a1 https://dk.um.si/Dokument.php?lang=slv&id=205215 Fakulteta za zdravstvene vede Medicinska fakulteta 0 0 0