20.500.12556/DKUM-97971 Prediction of suicide attempts in depressive disorder and panic disorder with/without agoraphobia multivariate analysis of clinical predictors Introduction: Suicide risk in patients with depressive disorder (DD) and panic disorder with or without agoraphobia (PD/A) is often associated with depression, hopelessness, and anxiety-related factors, but their predictive roles remain unclear.Aim: To identify the strongest clinical predictors of suicide attempts in patients with DD and PD/A, and to assess the applicability of a predictive model within and across diagnostic groups.Methods: A total of 94 patients (48 with DD- acute or recurrent, 46 with PD/A) were assessed using the Beck Scale for Suicide Ideation (BSSI), Beck Depression Inventory-II (BDI-II), Beck Hopelessness Scale (BHS), Anxiety Sensitivity Index-Revised (ASI-R), and Beck Anxiety Inventory (BAI). Univariate and multivariate analyses were conducted to evaluate the relative predictive value of these factors for suicide attempts within and across diagnostic groups.Results: Suicide attempts were reported by 23 patients with DD (48%) and only one patient with PD/A (2.17%). In DD sample, suicidal ideation was the strongest predictor of suicide attempts, followed by depression severity. ROC analyses indicated optimal cut-offs of 11 for BSSI and 35 for BDI-II, yielding high sensitivity (82.6%) and specificity (92%). Hopelessness and anxiety sensitivity did not retain predictive value in multivariate analysis, whereas panic/agoraphobic symptoms showed a suppressor effect, reducing risk by 11%. When applied to the PD/A group, the model estimated an average predicted risk of 9.3%, but failed to identify the single attempter, resulting in zero sensitivity.Conclusions: High levels of suicidal ideation and depressive symptoms were the strongest predictors of suicide attempts in DD. Panic and agoraphobic symptoms exerted a suppressor effect on suicide risk. In the PD/A group, however, the model’s predictive utility was extremely limited due to the very low number of suicide attempts, and these findings should therefore be considered preliminary. depressive disorder multivariate analysis panic disorder/agoraphobia prediction suicide attempts true true true Frontiers Angleški jezik Angleški jezik Znanstveno delo 2026-05-05 14:11:46 2026-05-05 14:18:56 2026-05-06 03:07:07 0000-00-00 00:00:00 2026 0 0 str. 1-8 Febr. 2026, št. članka 1710182 Letn. 17 Febr. 2026 0000-00-00 Zaloznikova Objavljeno NiDoloceno 2026-01-05 2026-01-27 2026-02-17 616.89 276164611 /10.3389/fpsyt.2026.1710182 1664-0640 RAZ_Batinic_Borjanka_2026.pdf RAZ_Batinic_Borjanka_2026.pdf 1 BA03D98095887D5DC445AE51E9AF5822 e0ad3381ea011c943daa033e8ce4b7b6863b57c8a436b6b09af44c22f3fe4599 37995fa0-487c-11f1-8e35-00155d0001a1 https://dk.um.si/Dokument.php?lang=slv&id=205787 https://doi.org/10.3389/fpsyt.2026.1710182 0 619d8522-487c-11f1-8e35-00155d0001a1 https://dk.um.si/Dokument.php?lang=slv&id=205788 https://www.frontiersin.org/journals/psychiatry/articles/10.3389/fpsyt.2026.1710182/full 1 854f3a31-487b-11f1-8e35-00155d0001a1 https://dk.um.si/Dokument.php?lang=slv&id=205785 Medicinska fakulteta 0 0 0