20.500.12556/DKUM-98332 Razvoj in optimizacija procesa sinteze furosemida magistrsko delo Fusosemide synthesis process development and optimization Magistrsko delo obravnava razvoj in optimizacijo procesa sinteze farmacevtske učinkovine furosemid s pomočjo z bakrom katalizirane Ullmannove kondenzacije. Namen dela je razvoj alternativne, trajnostne sintezne poti, ki z uporabo bakrove katalize in globoko evtektičnih topil (DES) nadomešča ostre reakcijske pogoje in strupena topila tradicionalnih industrijskih postopkov. V okviru eksperimentalnega dela je preučen vpliv različnih reakcijskih medijev, baz in bakrovih katalizatorjev na učinkovitost kondenzacije med 2,4-dikloro-5-sulfamoilbenzojsko kislino in furfurilaminom. Za nadaljnje sistematično raziskovanje eksperimentalnega prostora je uporabljen statistični pristop načrtovanja eksperimentov (DoE). Z delnim faktorskim presejalnim načrtom smo določili temperaturo, volumen topila in količino nukleofila kot ključne procesne parametre, ki smo jih nato optimizirali z metodo odzivnih površin (RSM). Ustreznost razvitega protokola smo potrdili z izvedbo reakcije na povečani skali ter izolacijo končnega produkta do farmacevtske čistosti. This master's thesis explores the development and optimization of a synthetic process for the active pharmaceutical ingredient furosemide, utilizing a copper-catalyzed Ullmann condensation. The aim of the research was to develop an alternative, sustainable synthetic pathway that replaces the harsh conditions and toxic solvents of traditional industrial procedures by employing copper catalysis and deep eutectic solvents (DES). During the experimental phase, the influence of various reaction media, bases, and copper catalysts on the efficiency of the condensation between 2,4-dichloro-5-sulfamoylbenzoic acid and furfurylamine was investigated. To further systematically explore the experimental space, a statistical Design of Experiments (DoE) approach was applied. Using a fractional factorial screening design, temperature, solvent volume, and nucleophile amount were identified as key process parameters, which were subsequently optimized using Response Surface Methodology (RSM). The feasibility of the developed protocol was confirmed by performing the reaction on a larger scale and isolating the final product to pharmaceutical-grade purity. Furosemid Načrtovanje eksperimentov Globoko evtektična topila Ullmannova kondenzacija Furosemide Design of experiments Deep eutetic solvents Ullmann condensation true true false [M. Berk Bevc] Slovenski jezik Angleški jezik Magistrsko delo/naloga 2026-06-05 11:30:12 2026-07-16 12:30:00 2026-07-17 03:09:22 0000-00-00 00:00:00 2026 0 Maribor 0 Maribor 1 spletni vir (1 datoteka PDF (XII, 47 str.)) 0000-00-00 NiDoloceno NiDoloceno NiDoloceno 0000-00-00 0000-00-00 0000-00-00 542.913:661.12(043.2) 285081603 MAG_Berk_Bevc_Miha_2026.pdf MAG_Berk_Bevc_Miha_2026.pdf 1 4E2D9737E8CBF59D38F1EDC78BAD32E4 08cd7db081e3d792fedd357e79f7d5ff5ddcdb0b99b73cb5c85837e00f9454ca d8c0aa5a-751d-11f1-9647-00155d580e34 https://dk.um.si/Dokument.php?lang=slv&id=207762 Fakulteta za kemijo in kemijsko tehnologijo 0 0 0