20.500.12556/DKUM-98966 Liposomal formulation of bioactive substances from mangifera indica peels for potential cosmetic applications Several sensitive bioactive substances are potent antioxidants that protect the skin from free radicals but are often rapidly degraded, limiting their effectiveness. Encapsulating these substances in liposomes improves their bioavailability and solubility and protects them from harmful environmental factors. The influence of liposomes as advanced lipid nanocarriers is increasing enormously due to their remarkable properties and protection of bioactive substances. For this reason, mango (Mangifera indica L.) peel extract (MPE), previously characterized and rich in various natural substances, including ellagic acid, gallic acid, and catechin, has been encapsulated in liposomes. The investigation focused on the impact of different liposome synthesis process parameters on their size, size distribution, stability, and encapsulation efficiency, and on in vitro release as a potential advanced MPE delivery system with suitable characteristics. An important study on the influence of the organic solvent used in liposome synthesis on the above properties is described. The thin lipid film hydration method using 5-mm glass beads and ethanol as an organic solvent was the most favorable method for synthesizing a stable and monodisperse lipid–MPE delivery system. MPE was successfully encapsulated in liposomes with the highest encapsulation efficiency of 53.7%. The sustained release of MPE from the liposomes was achieved, and the antibacterial properties of MPE, incorporated into the liposomes, were retained. For the first time, MPE has been encapsulated in liposomes, and with the remarkable results obtained, the extract represents a formulation with high added value that can be used in various fields, especially for the enrichment of different products such as cosmetic creams and lotion. liposomes synthesis zeta potential mango peels encapsulation in vitro release antibacterial activity liposomi sinteza zeta potencial true false true MDPI Angleški jezik Slovenski jezik https://www.mdpi.com/journal/ijms © 2026 by the authors Članek v reviji 2026-07-22 07:54:05 2026-07-22 07:54:06 2026-07-23 03:10:02 0000-00-00 00:00:00 2026 0 0 34 str. issue 13, [article no.] 5934 Vol. 27 2026 0000-00-00 Zaloznikova Objavljeno NiDoloceno 2026-05-19 2026-06-29 2026-07-01 66.02 283992579 10.3390/ijms27135934 1422-0067 https://www.mdpi.com/1422-0067/27/13/5934 1 c0d898a4-8591-11f1-a66a-00155d580e34 https://dk.um.si/Dokument.php?lang=slv&id=208492 ijms-27-05934_(1).pdf ijms-27-05934_(1).pdf 1 0AA03F98693C0AC5906C9C9EF121CF08 2e18a538be03c9f5b67b65f44b3c55bfc45805ccbe3ca644a6ff6b5c53d0cfba 52a06a93-8592-11f1-a66a-00155d580e34 https://dk.um.si/Dokument.php?lang=slv&id=208495 Fakulteta za kemijo in kemijsko tehnologijo 0 0 0