20.500.12556/DKUM-99629 Vpliv vrste odvzema krvi (kapilarni ali venski) na sedimentacijo eritrocitov z uporabo analizatorja mini cube The impact of blood collection method (capillary or yenous) on erythrocyte sedimentation using the mini-cube analyzer Hitrost sedimentacija eritrocitov (ESR) predstavlja eno izmed osnovnih laboratorijskih preiskav za oceno prisotnosti in intenzitete vnetnih procesov ter drugih patoloških stanj v organizmu. Na rezultat preiskave lahko vplivajo številni predanalitični, analitični in biološki dejavniki, med katerimi je pomembna tudi vrsta odvzema krvi. Namen magistrske naloge je bil raziskati vpliv vrste odvzema krvi - kapilarnega in venskega - na vrednosti ESR z uporabo analizatorja Mini-Cube. V raziskavo so bili vključeni preiskovanci, pri katerih sta bila izvedena oba načina odvzema krvi. Določitve ES so bile opravljene pod standardiziranimi laboratorijskimi pogoji z uporabo analizatorja Mini-Cube, ki omogoča avtomatizirano določanje sedimentacije iz manjšega volumna vzorca. Zbrane rezultate smo statistično analizirali z namenom ugotavljanja morebitnih razlik med kapilarnimi in venskimi vzorci ter ocene stopnje ujemanja med metodama. Rezultati raziskave so pokazali, da lahko vrsta odvzema krvi vpliva na določene vrednosti SE. Ugotovljene razlike med kapilarnimi in venskimi vzorci so bile ovrednotene z vidika klinične pomembnosti in uporabnosti metode v rutinski laboratorijski diagnostiki. Analiza je omogočila presojo zanesljivosti kapilarnega odvzema kot možne alternative venskemu odvzemu, predvsem v primerih, kjer je odvzem venske krvi otežen ali manj primeren. Ugotovili smo, da kapilarni odvzem krvi na analizatorju Mini-Cube zaradi reoloških omejitev, značilnosti mikrocirkulacije in tveganja za hemodilucijo s tkivno tekočino ne more predstavljati splošne alternative venskemu odvzemu. Metoda je primerna zgolj za presejalno testiranje zdrave populacije s pričakovanimi normalnimi vrednostmi, medtem ko venski odvzem za diagnostiko in spremljanje vnetnih stanj ostaja edina metodološko varna izbira. Erythrocyte sedimentation rate (ESR) represents one of the basic laboratory tests for assessing the presence and intensity of inflammatory processes and other pathological conditions in the body. The test result can be influenced by numerous pre-analytical, analytical, and biological factors, among which the type of blood collection is of significant importance. The purpose of this master's thesis was to investigate the influence of the blood collection type – capillary versus venous – on erythrocyte sedimentation rate values using the Mini-Cube analyzer.The study included subjects who underwent both methods of blood collection. Erythrocyte sedimentation rate measurements were performed under standardized laboratory conditions using the Mini-Cube analyzer, which enables automated determination of sedimentation from a smaller sample volume. The collected results were statistically analyzed to determine potential differences between capillary and venous samples and to assess the degree of agreement between the two methods.The results of the study showed that the type of blood collection can influence the measured values of erythrocyte sedimentation rate. The identified differences between capillary and venous samples were evaluated in terms of clinical significance and the utility of the method in routine laboratory diagnostics. The analysis enabled an assessment of the reliability of capillary collection as a potential alternative to venous collection, particularly in cases where venous blood collection is difficult or less suitable. We found that capillary blood collection on the Mini-Cube analyzer cannot represent a general alternative to venous collection due to the rheological limitations of microcirculation and the risk of hemodilution with tissue fluid. The method is only suitable for screening tests in a healthy population with expected normal values, whereas for the diagnosis and monitoring of inflammatory conditions, venous collection remains the only methodologically safe choice. sedimentacija eritrocitov kapilarna kri venska kri predanalitični dejavniki laboratorijska diagnostika Mini-Cube primerjalna analiza erythrocyte sedimentation rate capillary blood venous blood pre-analytical factors laboratory diagnostics Mini-Cube comparative analysis true true false Slovenski jezik Angleški jezik Magistrsko delo/naloga 2026-08-21 13:16:53 2026-09-16 17:53:01 2026-09-17 03:10:56 0000-00-00 00:00:00 2026 0 Maribor 0 0000-00-00 NiDoloceno NiDoloceno NiDoloceno 0000-00-00 0000-00-00 0000-00-00 MAG_Knap_Blazka_2026.pdf MAG_Knap_Blazka_2026.pdf 1 39321013CE9287591EFA2D9638A3E139 75682e71ebeddb6f4643b4ddf1014f9bfaaa2631848bb2503c370fffd23bdfe5 6bc01982-b1dc-11f1-b05b-00155d0001be https://dk.um.si/Dokument.php?lang=slv&id=212667 Fakulteta za kemijo in kemijsko tehnologijo 0 0 0