| Naslov: | Brain metastases in lung adenocarcinoma : impact of EGFR mutation status on incidence and survival |
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| Avtorji: | ID Stanič, Karmen (Avtor)
ID Zwitter, Matjaž (Avtor)
ID Turnšek Hitij, Nina (Avtor)
ID Kern, Izidor (Avtor)
ID Sadikov, Aleksander (Avtor)
ID Čufer, Tanja (Avtor) |
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| Datoteke: |  Radiology_and_Oncology_2014_Stanic_et_al._Brain_metastases_in_lung_adenocarcinoma_impact_of_EGFR_mutation_status_on_incidence_and_surviv.pdf (770,93 KB)
MD5: 627B4FE9C851BBA6971CBF943AC93216
 http://www.degruyter.com/view/j/raon.2014.48.issue-2/raon-2014-0016/raon-2014-0016.xml
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| Jezik: | Angleški jezik |
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| Vrsta gradiva: | Znanstveno delo |
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| Tipologija: | 1.01 - Izvirni znanstveni članek |
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| Organizacija: | MF - Medicinska fakulteta
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| Opis: | The brain represents a frequent progression site in lung adenocarcinoma. This study was designed to analyse the association between the epidermal growth factor receptor (EGFR) mutation status and the frequency of brain metastases (BM) and survival in routine clinical practice. Patients and methods. We retrospectively analysed the medical records of 629 patients with adenocarcinoma in Slovenia who were tested for EGFR mutations in order to analyse the cumulative incidence of BM, the time from the diagnosis to the development of BM (TDBM), the time from BM to death (TTD) and the median survival. Results. Out of 629 patients, 168 (27%) had BM, 90 patients already at the time of diagnosis. Additional 78 patients developed BM after a median interval of 14.3 months; 25.8 months in EGFR positive and 11.8 months in EGFR negative patients, respectively (p = 0.002). EGFR mutations were present in 47 (28%) patients with BM. The curves for cumulative incidence of BM in EGFR positive and negative patients demonstrate a trend for a higher incidence of BM in EGFR mutant patients at diagnosis (19% vs. 13%, p = 0.078), but no difference later during the course of the disease. The patients with BM at diagnosis had a statistically longer TTD (7.3 months) than patients who developed BM later (3.1 months). The TTD in EGFR positive patients with BM at diagnosis was longer than in EGFR negative patients (12.6 vs. 6.8, p = 0.005), while there was no impact of EGFR status on the TTD of patients who developed BM later. Conclusions. Except for a non-significant increase of frequency of BM at diagnosis in EGFR positive patients, EGFR status had no influence upon the cumulative incidence of BM. EGFR positive patients had a longer time to CNS progression. While EGFR positive patients with BM at diagnosis had a longer survival, EGFR status had no influence on TTD in patients who developed BM later during the course of disease. |
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| Ključne besede: | brain metastases, lung adenocarcinoma, EGFR mutations |
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| Status publikacije: | Objavljeno |
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| Verzija publikacije: | Objavljena publikacija |
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| Leto izida: | 2014 |
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| Št. strani: | str. 173-183, V |
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| Številčenje: | Letn. 48, št. 2 |
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| PID: | 20.500.12556/DKUM-65438  |
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| ISSN: | 1318-2099 |
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| UDK: | 616.2 |
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| COBISS.SI-ID: | 1803643 |
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| DOI: | 10.2478/raon-2014-0016 |
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| ISSN pri članku: | 1318-2099 |
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| NUK URN: | URN:SI:UM:DK:BQAI7PWJ |
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| Datum objave v DKUM: | 05.04.2017 |
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| Število ogledov: | 1329 |
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| Število prenosov: | 174 |
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| Metapodatki: |    |
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| Področja: | Ostalo
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