| Naslov: | Ultra-high-risk gestational choriocarcinoma of the ovary associated with ectopic pregnancy |
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| Avtorji: | ID Malovrh, Eva Pavla (Avtor)
ID Lukinovič, Nuša (Avtor)
ID Bujas, Tatjana (Avtor)
ID Sobočan, Monika (Avtor)
ID Knez, Jure (Avtor) |
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| Datoteke: |  Malovrh-2023-Ultra-High-Risk_Gestational_Chori.pdf (1,99 MB)
MD5: BD9025E2B782781AFE996755FF0BB3DF
 https://doi.org/10.3390/curroncol30020171
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| Jezik: | Angleški jezik |
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| Vrsta gradiva: | Znanstveno delo |
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| Tipologija: | 1.03 - Drugi znanstveni članki |
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| Organizacija: | MF - Medicinska fakulteta
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| Opis: | Gestational choriocarcinoma of the ovary is an exceptionally rare and highly aggressive tumor. Preoperative diagnosis of extrauterine choriocarcinoma is difficult due to nonspecific clinical presentation and its resemblance to ectopic pregnancy. Without molecular genetic analysis, it is not possible to reliably differentiate gestational from non-gestational choriocarcinoma. Here, we present a case of a 44-year-old woman who presented to our emergency department with complaints of pelvic pain, vaginal bleeding, and amenorrhea. Because of a recent history of conservatively managed ectopic pregnancy, the patient underwent emergency laparoscopy. Right-sided salpingo-oophorectomy was performed due to intraoperatively suspected ovarian ectopic pregnancy. Histopathology results revealed the diagnosis of ovarian choriocarcinoma of possible gestational origin. It was classified as FIGO stage IV and WHO ultra-high-risk, and she underwent multi-agent chemotherapy without major complications. She has remained in complete remission after a 12-month follow-up. Considering the rarity of this diagnosis, we conducted a literature review including all published cases of suspected gestational choriocarcinomas of the ovary. We conclude that due to the rarity of this entity, preoperative differentiating between ovarian ectopic pregnancy and ovarian choriocarcinoma is extremely challenging, and without molecular genetic analysis, it is not possible to identify the genetic origin of the tumor. |
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| Ključne besede: | ovarian choriocarcinoma, gestational trophoblastic neoplasia |
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| Status publikacije: | Objavljeno |
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| Verzija publikacije: | Objavljena publikacija |
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| Poslano v recenzijo: | 30.12.2022 |
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| Datum sprejetja članka: | 07.02.2023 |
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| Datum objave: | 11.02.2023 |
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| Založnik: | MDPI |
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| Leto izida: | 2023 |
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| Št. strani: | Str. 2217-2226 |
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| Številčenje: | Letn. 30, Št. 2 |
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| PID: | 20.500.12556/DKUM-87081  |
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| UDK: | 618.1 |
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| COBISS.SI-ID: | 141695747 |
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| DOI: | 10.3390/curroncol30020171 |
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| ISSN pri članku: | 1718-7729 |
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| Datum objave v DKUM: | 21.02.2024 |
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| Število ogledov: | 486 |
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| Število prenosov: | 21 |
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| Metapodatki: |    |
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| Področja: | Ostalo
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