| Naslov: | The role of anaplerotic metabolism of glucose and glutamine in insulin secretion : a model approach |
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| Avtorji: | ID Grubelnik, Vladimir (Avtor)
ID Zmazek, Jan (Avtor)
ID Gosak, Marko (Avtor)
ID Marhl, Marko (Avtor) |
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| Datoteke: |  RAZ_Grubelnik_Vladimir_2024.pdf (5,53 MB)
MD5: 9BE6724E24593D0E4240748D08D5F628
 https://www.sciencedirect.com/science/article/pii/S0301462224000991?via%3Dihub
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| Jezik: | Angleški jezik |
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| Vrsta gradiva: | Članek v reviji |
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| Tipologija: | 1.01 - Izvirni znanstveni članek |
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| Organizacija: | FERI - Fakulteta za elektrotehniko, računalništvo in informatiko
FNM - Fakulteta za naravoslovje in matematiko
MF - Medicinska fakulteta
PEF - Pedagoška fakulteta
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| Opis: | We propose a detailed computational beta cell model that emphasizes the role of anaplerotic metabolism under glucose and glucose-glutamine stimulation. This model goes beyond the traditional focus on mitochondrial oxidative phosphorylation and ATP-sensitive K+ channels, highlighting the predominant generation of ATP from phosphoenolpyruvate in the vicinity of KATP channels. It also underlines the modulatory role of H2O2 as a signaling molecule in the first phase of glucose-stimulated insulin secretion. In the second phase, the model emphasizes the critical role of anaplerotic pathways, activated by glucose stimulation via pyruvate carboxylase and by glutamine via glutamate dehydrogenase. It particularly focuses on the production of NADPH and glutamate as key enhancers of insulin secretion. The predictions of the model are consistent with empirical data, highlighting the complex interplay of metabolic pathways and emphasizing the primary role of glucose and the facilitating role of glutamine in insulin secretion. By delineating these crucial metabolic pathways, the model provides valuable insights into potential therapeutic targets for diabetes. |
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| Ključne besede: | mathematical models, pancreatic beta cell, pyruvate-malate cycle |
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| Status publikacije: | Objavljeno |
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| Verzija publikacije: | Objavljena publikacija |
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| Poslano v recenzijo: | 31.01.2024 |
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| Datum sprejetja članka: | 22.05.2024 |
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| Datum objave: | 23.05.2024 |
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| Leto izida: | 2024 |
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| Št. strani: | 16 str. |
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| Številčenje: | Vol. 311, [article no.] 107270 |
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| PID: | 20.500.12556/DKUM-89024  |
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| UDK: | 612.015.3 |
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| COBISS.SI-ID: | 197803779 |
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| DOI: | 10.1016/j.bpc.2024.107270 |
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| ISSN pri članku: | 0301-4622 |
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| Datum objave v DKUM: | 06.06.2024 |
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| Število ogledov: | 311 |
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| Število prenosov: | 52 |
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| Metapodatki: |    |
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| Področja: | Ostalo
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