| Naslov: | Enzyme cascade to enzyme complex phase-transition-like transformation studied by the maximum entropy production principle |
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| Avtorji: | ID Dobovišek, Andrej (Avtor)
ID Blaževič, Tina (Avtor)
ID Kralj, Samo (Avtor)
ID Fajmut, Aleš (Avtor) |
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| Datoteke: |  RAZ_Dobovisek_Andrej_2025.pdf (1,52 MB)
MD5: CD2D6DDEE8CD40E7E3FE54849D52C57A
 https://doi.org/10.1016/j.xcrp.2024.102400
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| Jezik: | Angleški jezik |
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| Vrsta gradiva: | Znanstveno delo |
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| Tipologija: | 1.01 - Izvirni znanstveni članek |
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| Organizacija: | FNM - Fakulteta za naravoslovje in matematiko
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| Opis: | In biological cells, soluble enzymes often spontaneously reorganize into higher-order complexes called metabolons, providing regulatory advantages over individual soluble enzymes under specific conditions. Despite their importance, the mechanisms underlying metabolon formation remain unclear. Here we report a theoretical model that elucidates the spontaneous transition between soluble enzyme cascades and complexes, driven by fluctuations in intermediate metabolite concentrations. The model integrates the maximum entropy production principle (MEPP) and the Shannon information entropy (MaxEnt), Landau phase-transition theory, kinetic modeling, stability analysis, and metabolic control analysis. Our results show that soluble enzymes and enzyme complexes represent two distinct catalytic states with unique kinetic and regulatory properties. The transition from an enzyme cascade to an enzyme complex displays features of a first-order phasetransition, highlighting the system's tendency to reorganize into its most thermodynamically favorable state, providing a potential pathway for metabolic regulation. |
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| Ključne besede: | theoretical modeling, irreversible thermodynamics, maximum entropy production principle, Shannon information entropy, first-order phase transition, enzyme organization, enzyme cascade, enzyme complex |
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| Status publikacije: | V tisku |
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| Poslano v recenzijo: | 16.11.2024 |
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| Datum sprejetja članka: | 30.12.2024 |
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| Datum objave: | 23.01.2025 |
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| Leto izida: | 2025 |
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| Št. strani: | str. 1-11 |
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| Številčenje: | Letn. 6, št. 2, št. članka 102400 |
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| PID: | 20.500.12556/DKUM-91789  |
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| UDK: | 536.7 |
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| COBISS.SI-ID: | 225246211 |
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| DOI: | 10.1016/j.xcrp.2024.102400 |
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| ISSN pri članku: | 2666-3864 |
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| Datum objave v DKUM: | 06.02.2025 |
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| Število ogledov: | 153 |
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| Število prenosov: | 10 |
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| Metapodatki: |    |
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| Področja: | Ostalo
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