| Naslov: | Diagnosis, clinical presentation and management of celiac disease in children and adolescents in Poland |
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| Avtorji: | ID Bierła, Joanna (Avtor)
ID Szaflarska-Popławska, Anna (Avtor)
ID Grzybowska-Chlebowczyk, Urszula (Avtor)
ID Oralewska, Beata (Avtor)
ID Cyba, Marta (Avtor)
ID Oracz, Grzegorz (Avtor)
ID Konopka, Ewa (Avtor)
ID Cukrowska, Božena (Avtor)
ID Syczewska, Małgorzata (Avtor)
ID Kołodziejczyk, Honorata (Avtor)
ID Rižnik, Petra (Avtor)
ID Dolinšek, Jernej (Avtor) |
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| Datoteke: |  Birela_2024_Diagnosis_Clinical_Presentation_and_Management.pdf (1,28 MB)
MD5: 3E9470EFF20D2A9E199027C2BB583ED2
 https://doi.org/10.3390/jcm13030765
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| Jezik: | Angleški jezik |
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| Vrsta gradiva: | Znanstveno delo |
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| Tipologija: | 1.01 - Izvirni znanstveni članek |
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| Organizacija: | MF - Medicinska fakulteta
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| Opis: | Celiac disease (CD) is a chronic immune-mediated disorder triggered by the ingestion of gluten in genetically predisposed individuals, affecting about 1% of the general population in the developed world. In 2012, the European Society for Pediatric Gastroenterology, Hepatology, and Nutrition (ESPGHAN) recommendations for CD diagnoses in children and adolescents were introduced, allowing the “no-biopsy” approach if certain criteria were met. This approach was also confirmed in the revised guidelines published in 2020. Thus, the aim of this study was to assess—over a one-year period—the clinical presentations and current status of the management of children and adolescents diagnosed with CD in Poland. Medical records of children and adolescents, newly diagnosed with CD in 2022/2023 in three medical centers in Poland, were involved. Gastroenterologists completed the specific anonymous web-based forms developed in the CD SKILLS project, including data routinely assessed at individual visits about the diagnostic approach and clinical presentation of the disease. Our study assessed 100 patients (56% girls) with an age range 1.6–18.0 years. We found that 98% of patients were serologically tested prior to a CD diagnosis and 58% of patients were diagnosed using the “no-biopsy” approach. In the analyzed group, 40% belonged to a known risk group, only 22% had annual screening before the CD diagnosis (the longest for 9 years), and 19% showed no symptoms at the time of the CD diagnosis. Our research confirmed the applicability of the “no-biopsy” approach for the diagnosis of CD in children and adolescents in Poland, and also showed changes in the clinical picture of CD. Moreover, we highlight the need to introduce broad CD serological screening in risk groups of the Polish population. |
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| Ključne besede: | celiac disease, no-biopsy, risk groups, Polish population |
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| Status publikacije: | Objavljeno |
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| Verzija publikacije: | Objavljena publikacija |
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| Poslano v recenzijo: | 30.11.2023 |
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| Datum sprejetja članka: | 25.01.2024 |
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| Datum objave: | 26.01.2024 |
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| Založnik: | MDPI |
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| Leto izida: | 2024 |
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| Št. strani: | Str. 1-13 |
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| Številčenje: | Letn. 13, št 3, št. članka 765 |
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| PID: | 20.500.12556/DKUM-92390  |
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| UDK: | 616.3 |
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| COBISS.SI-ID: | 183226115 |
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| DOI: | 10.3390/jcm13030765 |
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| ISSN pri članku: | 2077-0383 |
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| Datum objave v DKUM: | 04.04.2025 |
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| Število ogledov: | 179 |
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| Število prenosov: | 21 |
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| Metapodatki: |    |
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| Področja: | Ostalo
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