| Naslov: | Modular flow synthesis of citric acid-coated superparamagnetic iron oxide nanoparticles : preliminary results |
|---|
| Avtorji: | ID Vohl, Sabina (Avtor)
ID Nemet, Andreja (Avtor)
ID Stergar, Janja (Avtor) |
|---|
| Datoteke: |  micromachines-16-01228.pdf (1,54 MB)
MD5: 4842978EFB279A9E67161EA0A754F53B
|
|---|
| Jezik: | Angleški jezik |
|---|
| Vrsta gradiva: | Članek v reviji |
|---|
| Tipologija: | 1.01 - Izvirni znanstveni članek |
|---|
| Organizacija: | FKKT - Fakulteta za kemijo in kemijsko tehnologijo
|
|---|
| Opis: | Superparamagnetic iron oxide nanoparticles (SPIONs) with sizes below 10 nm are biocompatible and non-toxic, making them promising for biomedical applications. To prevent their agglomeration and enhance their functionality, the nanoparticles were coated with citric acid (CA), which modifies the surface charge, improves dispersion stability, and facilitates biomedical use. In this work, a modular flow-through microreactor system was employed to synthesize and coat the nanoparticles in a single, continuous two-step process. The system enables precise control over temperature and mixing, ensuring uniform reaction conditions and minimizing hot spots. The synthesized Fe3O4 nanoparticles exhibited an average crystallite size of ~5 nm (XRD) and particle sizes of 4–6 nm (TEM). FTIR analysis confirmed the successful surface functionalization with CA, while TGA indicated a coating mass fraction of approximately 4–20 wt%, increasing with higher CA concentration. Zeta potential measurements revealed strong colloidal stability, with values around −35 mV at pH 6.5. Among the tested CA concentrations, the sample with a molar ratio of Fe3O4:CA = 1:0.25 exhibited the most favorable properties, including narrow size distribution and improved dispersion stability. These findings demonstrate that the continuous modular flow approach enables the reproducible synthesis of highly stable, sub-10 nm CA-coated SPIONs, offering promising potential for biomedical applications, particularly as magnetic resonance imaging (MRI) contrast agents. |
|---|
| Ključne besede: | superparamagnetic iron oxide nanoparticles, citric acid, modular flow microreactor system, continuous synthesis, zeta potential measurements |
|---|
| Status publikacije: | Objavljeno |
|---|
| Verzija publikacije: | Objavljena publikacija |
|---|
| Poslano v recenzijo: | 13.10.2025 |
|---|
| Datum sprejetja članka: | 28.10.2025 |
|---|
| Datum objave: | 29.10.2025 |
|---|
| Založnik: | MDPI |
|---|
| Leto izida: | 2025 |
|---|
| Št. strani: | 13 str. |
|---|
| Številčenje: | Vol. 16, iss. 11, [article no.] 1228 |
|---|
| PID: | 20.500.12556/DKUM-95858  |
|---|
| UDK: | 620.3 |
|---|
| COBISS.SI-ID: | 255572227 |
|---|
| DOI: | 10.3390/mi16111228 |
|---|
| ISSN pri članku: | 2072-666X |
|---|
| Avtorske pravice: | © 2025 by the authors |
|---|
| Datum objave v DKUM: | 03.11.2025 |
|---|
| Število ogledov: | 141 |
|---|
| Število prenosov: | 15 |
|---|
| Metapodatki: |    |
|---|
| Področja: | Ostalo
|
|---|
|
:
|
Kopiraj citat |
|---|
| | | | Skupna ocena: | (0 glasov) |
|---|
| Vaša ocena: | Ocenjevanje je dovoljeno samo prijavljenim uporabnikom. |
|---|
| Objavi na: |  |
|---|
Postavite miškin kazalec na naslov za izpis povzetka. Klik na naslov izpiše
podrobnosti ali sproži prenos. |
