| Naslov: | 3D printed curcuminoid-loaded nanocellulose–alginate scaffolds with tunable mechanical and diffusion-controlled release properties |
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| Avtorji: | ID Slaček, Gal (Avtor)
ID Kotnik, Petra (Avtor)
ID Knez, Željko (Avtor)
ID Knez Marevci, Maša (Avtor)
ID Hribernik, Silvo (Avtor)
ID Stana-Kleinschek, Karin (Avtor)
ID Mohan, Tamilselvan (Avtor) |
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| Datoteke: |  polysaccharides-07-00084.pdf (2,81 MB)
MD5: 86ED9D7A44CC389A0AD8E8FC41574932
 https://www.mdpi.com/2673-4176/7/3/84
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| Jezik: | Angleški jezik |
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| Vrsta gradiva: | Članek v reviji |
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| Tipologija: | 1.01 - Izvirni znanstveni članek |
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| Organizacija: | FKKT - Fakulteta za kemijo in kemijsko tehnologijo
MF - Medicinska fakulteta
FERI - Fakulteta za elektrotehniko, računalništvo in informatiko
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| Opis: | This study reports the fabrication of curcuminoid-loaded nanofibrillated cellulose (NFC)– alginate scaffolds via extrusion-based 3D printing, integrating supercritical CO2 extraction with biofabrication. NFC–alginate inks were pre-crosslinked with CaCl2 (1 to 10 mM) to tune structure and properties. Rheological analysis confirmed shear-thinning behavior suitable for extrusion printing. Mechanical testing revealed a non-linear dependence on crosslinking: optimal performance was achieved by Ink 2 (1 mM CaCl2 with curcuminoid extract), with tensile strength increasing from ~0.60 to ~0.80 MPa and Young’s modulus from ~1.5 to ~3.0 MPa relative (Ink 1, 10 mM CaCl2, without extract), reflecting the combined effect of extract incorporation and ionic pre-crosslinking rather than crosslinker concentration alone; higher crosslinking reduced stiffness (~1.15 MPa). SEM revealed porous architectures (Ink 1: 542 ± 63 μm; Ink 4: 398 ± 71 μm) with increasing structural heterogeneity upon curcuminoid incorporation. In vitro release exhibited biphasic, diffusion-dominated behavior, reaching ~50 to 60% in ethanol-containing media; PBS inclusion as a physiological reference confirmed minimal release (<5%), consistent with the known hydrophobicity and pH-dependent instability of curcuminoids and defining the physicochemical delivery boundaries of the system. The highest release (~372 ng/mL) was achieved at intermediate loading (10×). Kinetic modeling confirmed Higuchi-type diffusion as the dominant mechanism (R2 ≈ 0.90 to 0.99). These results establish a clear structure–property–release relationship and position the scaffolds as a tunable, diffusioncontrolled delivery platform for hydrophobic bioactives in topical or formulation-assisted applications employing co-solvents or solubilizing excipients. |
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| Ključne besede: | nanocellulose, alginate, curcumin extract, supercritical-CO2, ionic-crosslinking, kinetic release and mechanical properties, 3D-printing |
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| Status publikacije: | Objavljeno |
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| Verzija publikacije: | Objavljena publikacija |
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| Poslano v recenzijo: | 21.04.2026 |
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| Datum sprejetja članka: | 07.07.2026 |
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| Datum objave: | 11.07.2026 |
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| Založnik: | MDPI |
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| Leto izida: | 2026 |
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| Št. strani: | 25 str. |
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| Številčenje: | Letn. 7, št. 3, št. članka 84 |
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| PID: | 20.500.12556/DKUM-98889  |
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| UDK: | 66 |
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| COBISS.SI-ID: | 284703491 |
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| DOI: | 10.3390/polysaccharides7030084 |
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| ISSN pri članku: | 2673-4176 |
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| Datum objave v DKUM: | 15.07.2026 |
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| Število ogledov: | 309 |
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| Število prenosov: | 13 |
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| Metapodatki: |    |
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| Področja: | Ostalo
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