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Title:Vpliv heterologne sklopitve na sinhronizacijo kalcijevih oscilacij celic alfa in beta : magistrsko delo
Authors:ID Goričan, Gorazd (Author)
ID Gosak, Marko (Mentor) More about this mentor... New window
ID Pohorec, Viljem (Comentor)
Files:.pdf MAG_Gorican_Gorazd_2026.pdf (13,92 MB)
MD5: 0C16854A24FF2B7F42B90CEEA39719E0
 
Language:Slovenian
Work type:Master's thesis/paper
Typology:2.09 - Master's Thesis
Organization:FNM - Faculty of Natural Sciences and Mathematics
Abstract:Preučujemo vpliv homolognih in heterolognih interakcij na sinhronizacijo počasnih kalcijevih oscilacij celic alfa in beta v Langerhansovem otočku. Analiza predhodno izmerjenih kalcijevih signalov je pokazala počasnejšo in bolj usklajeno aktivnost celic beta ter hitrejšo in bolj raznoliko aktivnost celic alfa. Ker iz meritev ni mogoče določiti smeri medceličnih vplivov, smo uporabili tridimenzionalni fazni model z ločenimi sklopitvami znotraj obeh populacij in med njima. Rezultati kažejo, da heterologna vpliva tvorita povratno zanko. Celice beta povečajo fazno urejenost in funkcionalno povezanost celic alfa, njihov spremenjeni odziv pa povratno vpliva na efektivno frekvenco celic beta in fazno razmerje med populacijama.
Keywords:Langerhansovi otočki, celice alfa, celice beta, kalcijeve oscilacije, heterologna sklopitev
Place of publishing:Maribor
Place of performance:Maribor
Publisher:[G. Goričan]
Year of publishing:2026
Number of pages:43 str.
PID:20.500.12556/DKUM-100174 New window
UDC:577:576.32/.36:616.379(043.2)
COBISS.SI-ID:291387651 New window
Publication date in DKUM:17.09.2026
Views:93
Downloads:2
Metadata:XML DC-XML DC-RDF
Categories:FNM
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Licences

License:CC BY 4.0, Creative Commons Attribution 4.0 International
Link:http://creativecommons.org/licenses/by/4.0/
Description:This is the standard Creative Commons license that gives others maximum freedom to do what they want with the work as long as they credit the author.
Licensing start date:07.09.2026

Secondary language

Language:English
Title:The effect of heterologous coupling on the synchronization of calcium oscillations of alpha and beta cells
Abstract:We examine how homologous and heterologous interactions affect the synchronization of slow calcium oscillations in alpha and beta cells of the islet of Langerhans. Analysis of previously acquired calcium signals revealed slower and more coordinated activity in beta cells and faster, more heterogeneous activity in alpha cells. Because the direction of intercellular influences cannot be determined from the measurements alone, we used a three-dimensional phase model with separate couplings within and between the two populations. The results show that the heterologous interactions form a feedback loop: beta cells increase the phase order and functional connectivity of alpha cells, whose altered response subsequently affects the effective frequency of beta cells and the phase relationship between the populations.
Keywords:islets of Langerhans, alpha cells, beta cells, calcium oscillations, heterologous coupling


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