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Title:KOPIČENJE PRESEŽKA ŽELEZA V ČLOVEŠKIH CELICAH IN VPLIV ZDRAVILA DEFERASIROX NA NJEGOVO IZPLAVLJANJE PRI LJUDEH, KI PREJEMAJO POGOSTE TRANSFUZIJE ERITROCITOV
Authors:ID Pernat, Ingrid (Author)
ID Glaser, Marjana (Mentor) More about this mentor... New window
ID Goropevšek, Aleš (Comentor)
Files:.pdf UNI_Pernat_Ingrid_2010.pdf (813,87 KB)
MD5: 3B7603EA84DED3EF6F1F8B29124397AE
PID: 20.500.12556/dkum/097382c3-66aa-461e-b8fb-c9223c4bef36
 
Language:Slovenian
Work type:Undergraduate thesis
Organization:FKKT - Faculty of Chemistry and Chemical Engineering
Abstract:Neželena posledica kroničnega zdravljenja s transfuzijami eritrocitov je čezmerno kopičenje železa v telesu, ki lahko povzroči okvaro srca, jeter in endokrinih žlez. Temu se lahko izognemo z zdravljenjem s helatorji. Za pravilno odločitev o začetku zdravljenja in za oceno uspešnosti so potrebne meritve obremenitve z železom. Najbolj običajen način merjenja je določitev koncentracije feritina v serumu. Ker vrsta stanj neodvisno od količine železa v telesu vpliva na koncentracijo feritina, preiskava pogosto ni natančna. Namen našega dela je bil oceniti obseg čezmernega kopičenja železa v telesu pri bolnikih na kroničnem zdravljenju s transfuzijami eritrocitov in oceniti vpliv zdravila deferasirox na njegovo izplavljanje iz telesa.
Keywords:Ključne besede: transfuzija, helatorji, feritin, železo, kopičenje, deferasirox
Place of publishing:Maribor
Publisher:[I. Pernat]
Year of publishing:2010
PID:20.500.12556/DKUM-16679 New window
UDC:616.15(043.2)
COBISS.SI-ID:14998550 New window
NUK URN:URN:SI:UM:DK:F8EPXNY1
Publication date in DKUM:17.11.2010
Views:3723
Downloads:295
Metadata:XML DC-XML DC-RDF
Categories:KTFMB - FKKT
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Secondary language

Language:English
Title:ACCUMULATION OF EXCESS IRON IN HUMAN CELLS AND IMPACT OF DEFERASIROX ON ITS ELIMINATION IN PATIENTS RECEIVING MULTIPLE RED BLOOD CELL TRANSFUSIONS
Abstract:Consequence of chronic transfusiontherapy is a secondary iron overload, which adversely affects the heart, liver and endocrine glands. This can be minimized by iron chelating therapy. The assessment of iron overload is essential to assign and adjust this treatment. Serum ferritin is a widely used marker for the estimation of iron stores. However, a variety of conditions alter the relationship between serum ferritin levels and body iron stores. The purpose of our work was to estimate iron overload in transfusion dependent patients and to estimate impact of deferasirox on its elimination from their bodies.
Keywords:transfusion, chelators, ferritin, iron, accumulation, deferasirox


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