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Title:VPLIV IMATINIB MESILATA NA DELOVANJE TIROZIN KINAZ RAKASTIH CELIC PRI KRONIČNI MIELOIČNI LEVKEMIJI
Authors:ID Rošker, Petrina (Author)
ID Glaser, Marjana (Mentor) More about this mentor... New window
ID Aleš, Goropevšek (Comentor)
Files:.pdf UNI_Rosker_Petrina_2011.pdf (1,63 MB)
MD5: 76F4CBA7C702CEB165E94E5F405AE527
PID: 20.500.12556/dkum/692eede3-dc40-4d4e-8950-c8e47198272e
 
Language:Slovenian
Work type:Undergraduate thesis
Organization:FKKT - Faculty of Chemistry and Chemical Engineering
Abstract:Namen diplomske naloge je raziskati uspeh zdravljenja bolnikov s kronično mieloično levkemijo, in sicer z imatinib mesilatom, ki deluje kot inhibitor tirozin kinaz. V ta namen smo preučili laboratorijske izvide sedmih bolnikov. Določili smo krvno sliko z razmazom, na podlagi katere smo nato ugotovili diagnozo, in prisotnost kromosoma Philadelphia, ki diagnozo potrdi, pri čemer njegova neprisotnost pri zdravljenju pomeni citogenetsko remisijo. Ugotavljali smo še prisotnost BCR-ABL onkogena, saj neprisotnost BCR-ABL onkogena iz bolnikove krvi pomeni molekularno remisijo, kar pomeni popolno ozdravitev. Ugotovili smo, da se je zdravljenje izkazalo za zelo uspešno. Pri treh bolnikih smo dosegli glavni molekularni odgovor, pri dveh popolni molekularni odgovor, pri enem popolni citogenetski odgovor. En bolnik se na zdravljenje z imatinib mesilatom ni odzval.
Keywords:kinaza, levkemija, levkociti, imatinib
Place of publishing:Maribor
Publisher:[P. Rošker]
Year of publishing:2011
PID:20.500.12556/DKUM-17728 New window
UDC:616.155.392:579(043.2)
COBISS.SI-ID:15151126 New window
NUK URN:URN:SI:UM:DK:R4DYQPBT
Publication date in DKUM:24.03.2011
Views:3468
Downloads:327
Metadata:XML DC-XML DC-RDF
Categories:KTFMB - FKKT
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Secondary language

Language:English
Title:IMPACT OF IMATINIB MESILATE ON TYROSINE KINASES OF CANCER CELLS IN CRONIC MYELOGENOUS LEUKEMIA
Abstract:The purpose of this thesis is to research treatment success in cases of patients with a chronic myelogenous leukemia with the tyrosine kinases inhibitor imatinib mesilate. For this purpose, we examined the laboratory findings of seven patients. We defined the blood count with a spread, on the basis of which we established the diagnosis, and the occurance of Philadelphia chromosome, which confirms the diagnosis, while its absence in treatment signifies the cytogenetic remission. In addition, we also determined the presence of BCR-ABL oncogene where the absence of BCR-ABL oncogene in patient´s blood indicates the molecular remission, which signifies complete recovery. We found out that this treatment proved to be very successful. In case of three patients we attained the major molecular response, two of them reached complete molecular response, and one complete cytogenetic response. One patient did not accede to treatment with imatinib mesilate.
Keywords:kinase, leucocytes, leukemia, imatinib


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