BIOSENZORJI IN MERJENJE GLUKOZE V BIOLOŠKIH MATERIALIH

Slodej, Lana

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Title:	BIOSENZORJI IN MERJENJE GLUKOZE V BIOLOŠKIH MATERIALIH
Authors:	ID Slodej, Lana (Author) ID Glaser, Marjana (Mentor) More about this mentor... ID Gošnjak, Matej (Comentor)
Files:	UNI_Slodej_Lana_2011.pdf (2,51 MB) MD5: 0E7641E2E4F27E400D9AD12F71DEDEEA PID: 20.500.12556/dkum/e398fc09-829a-42d6-a8a9-b52746900e75
Language:	Slovenian
Work type:	Undergraduate thesis
Organization:	FKKT - Faculty of Chemistry and Chemical Engineering
Abstract:	Nekatere laboratorijske preiskave se lahko izvajajo tudi izven laboratorijev. To so t.i. obposteljne preiskave ali angleško POCT. Seveda se te preiskave ne opravljajo na pravih laboratorijskih merilnih instrumentih, ker so le-ti prekompleksni, fiksni in že zaradi svoje velikosti neprimerni v ta namen. Zato se na oddelkih in ambulantah poslužujejo manjših, prenosnih sistemov, ki pa običajno uporabljajo tudi drugačno tehnologijo merjenja kot laboratorijski. Eden takih najbolj razširjenih sistemov so biosenzorji, ki se uporabljajo zlasti pri meritvah glukoze v bioloških materialih. Ker se morajo te meritve opraviti hitro in enostavno, se najpogosteje opravi meritev kar v kapljici polne krvi. S tem pa se pojavi še ena razlika – namreč laboratorijski analitični sistemi merijo koncentracijo glukoze v plazmi ali serumu. Posledica teh razlik je lahko zmanjšana primerljivost rezultatov. Še dodatno pa lahko te razlike povečajo tudi predanalitični dejavniki, zlasti ker je sam analit, t.j. glukoza v krvi, nestabilen zaradi prisotnosti živih celic in delovanja glikolitičnih procesov v njih. V nalogi smo poskusili primerjati nekaj takšnih analitičnih sistemov in jih ovrednotiti s pomočjo ustreznih statističnih metod.
Keywords:	glukoza, biosenzorji, POCT, laboratorijske metode
Place of publishing:	Maribor
Publisher:	[L. Slodej]
Year of publishing:	2011
PID:	20.500.12556/DKUM-18946
UDC:	577.1(043.2)
COBISS.SI-ID:	15157014
NUK URN:	URN:SI:UM:DK:UWV6FB1H
Publication date in DKUM:	23.06.2011
Views:	3808
Downloads:	497
Metadata:
Categories:	KTFMB - FKKT
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Secondary language

Language:	English
Title:	BIOSENSORS AND GLUCOSE MEASURING IN BIOLOGICAL FLUIDS
Abstract:	Some laboratory tests may be conducted outside the laboratory. These are the so-called Point of care investigation (POCT). Of course, these investigations are not carried out in real laboratory measuring instruments, because they are too complex, fixed and due to its size inappropriate. Therefore, the departments and clinics make use of smaller, portable systems, usually using a different technology than laboratory measurements. One of those most widely used systems are biosensors that are used in particular for measuring glucose in biological materials. Since these measurements are supposed to be done quickly and easily the most common practice is to simply do the measurement in a drop of whole blood. Thus, there is another difference–namely, the laboratory analytical systems measure glucose in plasma or serum. The result of these differences can be reduced comparability of results. Further and these differences may also increase pre–analytical factors, particularly as the analyte itself, blood glucose is unstable due to the presence of living cells and the glycolytic processes in them. In this diploma paper we try to compare some of these analytical systems and evaluate them using appropriate statistical methods.
Keywords:	glucose, biosensors, POCT, laboratory methods

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