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Title:SIMULACIJE UČINKOVANJA RAZLIČNIH ZDRAVIL NA PRODUKCIJO EIKOZANOIDOV Z MODELOM PRESNOVE ARAHIDONSKE KISLINE IN APLIKACIJA NA ASPIRINSKO INTOLERANCO
Authors:ID Ferk, Sonja (Author)
ID Fajmut, Aleš (Mentor) More about this mentor... New window
Files:.pdf UNI_Ferk_Sonja_2012.pdf (1000,23 KB)
MD5: 70C851D991975B104BF7EBAB5621F9AC
PID: 20.500.12556/dkum/4363669a-a431-4889-8aaf-2c4b5d220148
 
Language:Slovenian
Work type:Undergraduate thesis
Typology:2.11 - Undergraduate Thesis
Organization:FNM - Faculty of Natural Sciences and Mathematics
Abstract:V diplomskem seminarju z matematičnim modelom presnove arahidonske kisline preučujemo vpliv nesteroidnih antirevmatikov (NSAR) na pojav bronhokonstrikcije pri aspirinsko intolerantnih astmatikih. Za tri različne populacije aspirinsko-intolerantnih astmatikov ocenimo, pri kateri dozi indometacina in etoricoxiba se tveganje za simptome aspirinske intolerance poveča in ocenimo, kako dolgo traja bronhokonstrikcija pri tipični terapevtski dozi indometacina. Preučujemo tudi strategijo, pri kateri aspirin, ibuprofen ali indometacin doziramo skupaj z inhibitorjem encima 5-lipoksigenaze. Ta strategija bi lahko omogočila varno doziranje nesteroidnih antirevmatikov aspirinsko-intolerantnim astmatikom brez tveganja bronhokonstrikcije.
Keywords:matematični model, arahidonska kislina, nesteroidni antirevmatiki, astma, aspirinska intoleranca, zdravila, farmakokinetika
Place of publishing:Maribor
Publisher:[S. Ferk]
Year of publishing:2012
PID:20.500.12556/DKUM-36580 New window
UDC:53(043.2)
COBISS.SI-ID:19247624 New window
NUK URN:URN:SI:UM:DK:ZZVVXDOO
Publication date in DKUM:16.07.2012
Views:2457
Downloads:172
Metadata:XML DC-XML DC-RDF
Categories:FNM
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Secondary language

Language:English
Title:SIMULATIONS OF THE EFFECTS OF DIFFERENT DRUGS ON THE PRODUCTION OF EICOZANOIDS WITH THE MATHEMATICAL MODEL OF ARACHIDONIC ACID METABOLISM AND ITS APPLICATION TO ASPIRIN - INDUCED ASTHMA
Abstract:In this diploma work we studied the impact of non-steroidal anti-inflammatory drugs (NSAIDs) on the occurrence of bronchoconstriction in aspirin-intolerant asthmatic patients. For this purpose a mathematical model is used to describe the interaction between NSAID with arachidonic acid metabolism in white blood cells. We estimated, for three different populations of aspirin-intolerant asthmatic patients, at which doses of indomethacin and etoricoxib the risk of bronchoconstriction is increased. In addition, the duration of bronchoconstriction is theoretically estimated for typical therapeutic dose of indomethacin. We also study the strategy for safe managing of NSAIDs to aspirin-intolerant asthmatic patients in combination with inhibitor of the enzyme 5- lipoksigenaze (5-LOX) without risk of bronchoconstriction.
Keywords:mathematical model, arachidonic acid, non-steroidal anti-inflammatory drugs, asthma, aspirin intolerance asthmatic patients, pharmacokinetics


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