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Title:Viskoelastični model izometrične kontrakcije gladkih mišic
Authors:ID Emeršič, Tadej (Author)
ID Fajmut, Aleš (Mentor) More about this mentor... New window
Files:.pdf UNI_Emersic_Tadej_2012.pdf (1,27 MB)
MD5: 2F4AFEE3E724E8D60ECBD352ECBFE81A
PID: 20.500.12556/dkum/725d4813-d23d-48ba-88f1-737220088013
 
Language:Slovenian
Work type:Final seminar paper
Typology:2.11 - Undergraduate Thesis
Organization:FNM - Faculty of Natural Sciences and Mathematics
Abstract:V seminarju obravnavamo mehanizme razvoja sile v gladki mišični celici dihalnih poti ob holinergični stimulaciji. Pri tem obravnavamo od kalcija odvisen razvoj sile, ki upošteva podroben opis od kalcija in kalmodulina odvisne aktivacije encima kinaze lahkih verig miozina in aktivnost fosfataze lahkih verig miozina. Obstoječi model nadgradimo z elementi, ki opisujejo viskoelastične lastnosti gladkih mišičnih celic arterij. Modelni rezultati napovejo zakasnitve v razvoju sile, kar je bolj v skladu z meritvami kot pri predhodnih modelih.
Keywords:viskoelastični model, izometrična kontrakcija, gladka mišična celica, holinergična stimulacija, prečni mostički, kalcij, kalmodulin, kinaza lahkih verig miozina
Place of publishing:Maribor
Publisher:[T. Emeršič]
Year of publishing:2012
PID:20.500.12556/DKUM-37658 New window
UDC:53(043.2)
COBISS.SI-ID:19345160 New window
NUK URN:URN:SI:UM:DK:HMQ3XXHW
Publication date in DKUM:03.02.2021
Views:2154
Downloads:53
Metadata:XML DC-XML DC-RDF
Categories:FNM
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Secondary language

Language:English
Title:Viskoelastični model izometrične kontrakcije gladkih mišic
Abstract:In this work we study mechanisms of stress development in an airway smooth muscle cell upon the cholinergic stimulation. In this case, the stress development is calcium dependent and includes activation of the calcium - calmodulin dependent myosin light chain kinase and activation of a myosin light chain phosphatase. The existing model is upgraded by the viscoelastic elements, that describe viscoelastic properties of smooth muscle cells of arteries. The model predicts a delay in the development of stress which gives better agreement with experimental results than the previous models.
Keywords:viscoelastic model, isometric contraction, smooth muscle cell, cholinergic stimulation, cross bridge, calcium, calmodulin, myosin light chain kinase


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