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Title:Pomen molekularne diagnostike za zdravljenje bolnikov s sepso in večorgansko odpovedjo
Authors:ID Markota, Andrej (Author)
ID Sinkovič, Andreja (Mentor) More about this mentor... New window
ID Poljak, Mario (Comentor)
Files:.pdf DOK_Markota_Andrej_2016.pdf (3,29 MB)
MD5: E8E7A9F110DC86AFDCA99258A9CE89C6
 
Language:Slovenian
Work type:Doctoral dissertation
Organization:MF - Faculty of Medicine
Abstract:Sepsa je življenje ogrožujoče stanje, ki jo povzroči okužba in za katero je značilen sindrom sistemskega vnetnega odziva. Umrljivost za za septičnim šokom je 40-80%. Ob uvedbi antibiotičnega zdravljenja povzročitelja sepse večinoma ne poznamo in je začetna izbira antibiotika večinoma izkustvena. Ker je začetna izbira antibiotičnega zdravljenja izkustvena, približno 20% bolnikov s sepso ne prejme ustreznega antibiotika. Izbira ustreznega antibiotika je pomembna, saj ustrezno začetno antibiotično zdravljenje zmanjša umrljivost bolnikov s sepso. Osamitev povzročitelja s standardnimi hemokulturami navadno traja vsaj 24 ur.Novejše metode določanja povzročiteljev, ki temeljijo na verižni reakciji s polimerazo (iz ang. polymerase chain reaction), omogočajo hitrejšo zaznavo povzročitelja in posledično hitrejšo uvedbo ustreznega antibiotičnega zdravljenja. Vloga verižne reakcije s polimerazo pri zdravljenju bolnikov s sepso ni popolnoma pojasnjena.
Keywords:sepsa, verižna reakcija s polimerazo, hemokulture, protimikrobna zdravila, osamitev povzročitelja
Place of publishing:Maribor
Year of publishing:2015
PID:20.500.12556/DKUM-47870 New window
COBISS.SI-ID:5846335 New window
NUK URN:URN:SI:UM:DK:W8I9EHJ3
Publication date in DKUM:19.12.2016
Views:30389
Downloads:301
Metadata:XML DC-XML DC-RDF
Categories:MF
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Secondary language

Language:English
Title:ROLE OF MOLECULAR DIAGNOSTIC IN TREATMENT OF PATIENTS WITH SEPSIS AND MULTIORGAN FAILURES
Abstract:Sepsis is a life-threatening condition caused by infection and characterized by signs of systemic inflammatory response syndrome. The mortality rate is around 10-20% for sepsis, 20-50% for severe sepsis and 40-80% for septic shock. Since the initial choice of antibiotics is, in most cases, empirical, approximately 20% of patients with sepsis do not receive an appropriate antibiotic. Early appropriate antibiotic therapy is important because of reduction in mortality. To isolate pathogens by using standard blood cultures usually takes around 24 hours to the first, incomplete results, and about 3-5 days to complete test results including resistance to antibiotics. Newer methods of pathogen isolation, based on polymerase chain reaction, enable more rapid pathogen isolation and possibly faster institution of appropriate antibiotic therapy. In studies that have been performed so far using polymerase chain reaction assay in sepsis, different patient populations have been included, ranging from patients with fever to patients with septic shock and multi-organ failure, from patients who were treated in emergency departments and various hospital wards to intensive care units, studies included pediatric patients and adults. The role of polymerase chain reaction assay in the treatment of cohort of patients with severe sepsis and septic shock has not been defined.
Keywords:sepsis, polymerase chain reaction, blood cultures, antimicrobial agents, pathogen identification


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