Redek vzrok Cushingovega sindroma

Zemljič, Eva; Čokolič, Miro

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Title:	Redek vzrok Cushingovega sindroma
Authors:	ID Zemljič, Eva (Author) ID Čokolič, Miro (Author)
Files:	http://www.medrazgl.si/e107_files/public/datoteke/mr02_1_08.pdf
Language:	Slovenian
Work type:	Not categorized
Typology:	1.04 - Professional Article
Organization:	UM - University of Maribor
Abstract:	Cushingov sindrom je skupek kliničnih znakov in simptomov, ki so posledica povišanih količin glukokortikoidov v telesu. Delimo ga lahko v dve veliki skupini: prvo, kjer visoke vrednostikortikotropina vzpodbudijo skorjo nadledvične žleze k povečani tvorbi glukokortikoidov (od kortikotropina odvisni Cushingov sindrom), in drugo, kjer je Cushingov sindrom posledica povečanega izločanja glukokortikoidov iz bolezensko spremenjene nadledvične žleze (od kortikotropina neodvisni Cushingov sindrom). Redek vzrok Cushingovega sindroma je ektopični tumor, ki povečano izloča kortikotropin. V klinični sliki ektopičnega Cushingovega sindroma prevladuje povišan krvni tlak, edemi, hipokalijemija in intoleranca za glukozo. Najpogosteje je povezan z drobnoceličnim karcinomom pljuč, redkeje s karcinoidi, tumorji trebušne slinavke, tumorji timusa ali medularnimi karcinomi ščitnice. Zdravljenje ektopičnega Cushingovega sindroma je, dokler ne odkrijemo vzroka, simptomatsko, ko je vzrok znan, pa vzorčno.
Year of publishing:	2002
Number of pages:	str. 83-88
Numbering:	Letn. 41, št. 1
PID:	20.500.12556/DKUM-55935
UDC:	616.4
ISSN on article:	0025-8121
COBISS.SI-ID:	1015103
NUK URN:	URN:SI:UM:DK:I6RA6MZ3
Publication date in DKUM:	21.12.2015
Views:	2105
Downloads:	58
Metadata:
Categories:	Misc.
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Record is a part of a journal

Title:	Medicinski razgledi. [medicinski pregledni, strokovni in raziskovalni članki]
Shortened title:	Med. razgl.
Publisher:	Medicinski razgledi
ISSN:	0025-8121
COBISS.SI-ID:	3390978

Secondary language

Language:	English
Title:	Rare cause of Cushing's syndrom
Abstract:	Cushing's syndrome is the term used to describe clinical symptoms and signs related to an increased concentration of glucocorticoids in the body. Cushing's syndrome can be divided into two categories: corticotropin-dependent Cushing's syndrome, in which abnormally high plasma corticotropin levels stimulate the adrenal cortex to produce excessive amounts of glucocorticoids, and corticotropin-independent Cushing's syndrome, in which excessive production of glucocortioids is due to abnormal adrenocortical tissue. In rare cases, the cause of Cushing's syndrome may be an ectopic tumor which secretes corticotropin. The main clinical symptoms of ectopic Cushing's syndrome include high blood pressure, edema, hypokalemia and glucose intolerance. Ectopic corticotropin production is most commonly found in pulmonary small cell carcinoma and rarely in carcinoid tumors, islet cell carcinoma of the pancreas, thymoma and medullary thyroid carcinoma. Treatment of ectopic Cushing's syndrome is initially symptomatic; when the cause of the syndrome has been established, it can be etiologic.

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