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Title:Serumski cistatin C - nov označevalec glomerulne filtracije
Authors:ID Bevc, Sebastjan (Author)
ID Ekart, Robert (Author)
ID Hojs, Radovan (Author)
Files:URL http://www.medrazgl.si/e107_files/public/datoteke/mr06_3_07.pdf
 
Language:Slovenian
Work type:Not categorized
Typology:1.02 - Review Article
Organization:UM - University of Maribor
Abstract:Glomerulna filtracija (GF) je najpomembnejši pokazatelj ledvične funkcije. Ocena GF je pomembna za obravnavo in spremljanje bolnika z ledvično boleznijo. V vsakdanji klinični praksi se za oceno GF najpogosteje uporabljata koncentracija serumskega kreatinina in očistek kreatinina, kot standardna referenčna metoda za določanje GF pa očistek radioizotopnega označevalca. V zadnjem času se kot eden novih označevalcev glomerulne filtracije pojavlja serumski cistatin C, inhibitor proteaz, ki v telesu nastaja stalno v vseh jedrnih celicah in se zaradi svoje majhnosti prosto filtrira v glomerulu. Za razliko od kreatinina koncentracija cistatina C ni odvisna od mišične mase, starosti, spola in načina ter vrste prehrane. Številne raziskave so potrdile, da je serumski cistatin C dober označevalec GF. V določenih populacijah bolnikov z ledvično boleznijo se je koncentracija serumskega cistatina C pokazala kot boljši pokazatelj GF od koncentracije serumskega kreatinina.
Year of publishing:2006
Number of pages:str. 293-299
Numbering:Letn. 45, št. 3
PID:20.500.12556/DKUM-56044 New window
UDC:616.61-008.6
ISSN on article:0025-8121
COBISS.SI-ID:2579007 New window
NUK URN:URN:SI:UM:DK:6B1SLD3C
Publication date in DKUM:21.12.2015
Views:3180
Downloads:82
Metadata:XML DC-XML DC-RDF
Categories:Misc.
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Record is a part of a journal

Title:Medicinski razgledi. [medicinski pregledni, strokovni in raziskovalni članki]
Shortened title:Med. razgl.
Publisher:Medicinski razgledi
ISSN:0025-8121
COBISS.SI-ID:3390978 New window

Secondary language

Language:English
Title:Serum cystatin C - a new marker of glomerular filtration rate
Abstract:The glomerular filtration rate (GFR) is the main indicator of kidney function and GFR estimation is essential for the evaluation of patients with chronic kidney disease. In clinical practice, serum creatinine levels and creatinine clearance are the most commonly used markers to estimate GFR. The standard GFR estimation method is based on the clearance of a radionuclide-labelled marker. Recently, serum cystatin C has been proposed as a new endogenous GFR marker. This protease inhibitor with a low molecular weight is produced at a constant rate by all nucleated cells and is freely filtered across the glomerular membrane. Contrary to serum creatinine, serum cystatin C does not depend on muscle mass, sex, age or dietary protein intake. This study confirmed that serum cystatin C is a reliable marker of GFR. Serum cystatin C had a higher diagnostic accuracy than serum creatinine and also creatinine clearance in well-defined patients with chronic kidney disease.


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