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Title:
Primarni sklerozantni holangitis
Authors:
ID
Dajčman, Davorin
(
Author
)
Files:
http://www.dlib.si/details/URN:NBN:SI:DOC-QYDX6RX9
Language:
Slovenian
Work type:
Not categorized
Typology:
1.02 - Review Article
Organization:
UM - University of Maribor
Abstract:
The aetiology and pathogenesis of the inflammatory and fibrotic bile duct lesions characteristic of primary sclerosing cholangitis is unknown, but several lines evidence support connection that genetic and immunologic factorsare involved. Disease is characterised by ongoing inflammation, destruction and fibrosis of intrahepatic and extrahepatic bile duct. Irreversible damage to the bile ducts leads cholestasis, cirrhosis and liver failure with premature death unless liver transplantation is performed. It is frequently associated with inflammatory bowel disease, usually ulcerative colbis. There is no satisfactory medical therapy for patients with primary sclerosing cholangitis. Lacking a specific remedy the goal of treatment is controlling inflammation and infection and to prevent scaring. Liver transplantation is treatment of choice in advanced liver disease.
Year of publishing:
1999
Number of pages:
str. 239-252
Numbering:
Letn. 38, št. 2
PID:
20.500.12556/DKUM-56181
UDC:
616.3
ISSN on article:
0025-8121
COBISS.SI-ID:
10799321
NUK URN:
URN:SI:UM:DK:8UT3UXTQ
Publication date in DKUM:
21.12.2015
Views:
1963
Downloads:
81
Metadata:
Categories:
Misc.
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Record is a part of a journal
Title:
Medicinski razgledi. [medicinski pregledni, strokovni in raziskovalni članki]
Shortened title:
Med. razgl.
Publisher:
Medicinski razgledi
ISSN:
0025-8121
COBISS.SI-ID:
3390978
Secondary language
Language:
English
Title:
Primary sclerosing cholangitis
Abstract:
Izvleček. Etiologija in patogeneza vnetnega dogajanja in fibroze žolčnih vodovpri bolnikih s primarnim sklerozantnim holangitisom še ni pojasnjena. Obstajajo številni dokazi o tesni zvezi z genetskimi in imunskimi dejavniki. Za bolezen je značilno vnetje, propad in fibroza znotraj jetrnih in zunaj jetrnih žolčnih vodov. Trajna okvara žolčnih vodov vodi do holestaze, ciroze in odpovedi jeter, ki se brez presaditve jeter konča smrtno. Pogosto sovpada skroničnim vnetnim črevesnim obolenjem, najpogosteje z ulceroznim kolitisom. Še zmeraj ne poznamo zadovoljivega zdravijenja z zdravili, zato ostaja bistvo zdravljenja v obvladovanju vnetja, preprečevanju okužb in zaviranju brazgotinjenja. Izborno zdravljenje v napredovalih bolezenskih obdobjih je presaditev jeter.
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