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Title:Nove metode za ocenjevanje tveganja za razvoj metaboličnega sindroma pri otrocih
Authors:ID Vogrin, Bernarda (Author)
ID Slak Rupnik, Marjan (Mentor) More about this mentor... New window
ID Mičetić Turk, Dušanka (Comentor)
Files:.pdf DOK_Vogrin_Bernarda_2017.pdf (1,91 MB)
MD5: 1464577AB5233C58456F5F920314B62E
 
Language:Slovenian
Work type:Doctoral dissertation
Organization:MF - Faculty of Medicine
Abstract:Uvod. Zaradi epidemije otroške debelosti in metaboličnega sindroma lahko v prihodnosti pri otrocih pričakujemo še večje obremenitve srca in žil, čemur smo priča danes. Zgodnje odkrivanje oseb, ki so nagnjene k metaboličnim motnjam in boleznim srca in žil, lahko bistveno pripomore k načrtovanju preventive in zdravljenju bolezni. Hipoteza. Z merjenjem žilne funkcije, telesne sestave in natančno analizo serumskih lipidov lahko odkrijemo nagnjenost k metaboličnemu sindromu in boleznim srca in žil že v otroštvu, še pred pojavom kliničnih znakov. Metode. V študiji je sodelovalo 81 šolarjev starih 11–16 let. Z anketnim vprašalnikom smo pridobili podatke o njihovem socialnem okolju, prehranskih navadah in učnem uspehu. Z analizo športno vzgojnih kartonov smo ocenili njihovo telesno zmogljivost. Opravili smo meritve telesne konstitucije: telesno višino (TV), telesno težo (TT), obseg pasu (OP) in bokov (OB), kožno gubo na nadlahti (KGN) ter izračunali indeks telesne mase (BMI) in standardni odklon glede na spol in starost (SDS BMI). Telesno sestavo (odstotek maščobe (FAT %)) smo ocenjevali z bioimpedanco. Lastnosti arterijskega sistema smo merili z Arteriografom, z določanjem augmentacijskega indeksa (AIx), hitrosti pulznih valov (PWV) in centralnega sistoličnega arterijskega tlaka (SBPao). V vzorcu venozne krvi smo analizirali glukozo (GLU) in serumske lipide vključno s prostimi maščobnimi kislinami (PMK). Rezultati. AIx je značilno koreliral s TV, učnim uspehom, nekaterimi motoričnimi testi in serumskimi lipidi. PWV je značilno koreliral s TT, TV, BMI, SDS BMI, OP, OB, nekaterimi motoričnimi testi in PMK. SBPao je negativno koreliral z učnim uspehom. FAT % je kazal značilne povezave z GLU, PMK in drugimi lipidi. Pri 5 % oziroma 6 % učencev smo ugotovili zelo visoke vrednosti AIx, SBPao in PWV. Zaključki. AIx, PWV, PMK in FAT % so dobri pokazatelji začetnih žilnih in metaboličnih nepravilnosti pri otrocih in mladostnikih. Zvečana AIx in SBPao sta povezana s slabšimi učnimi in motoričnimi sposobnostmi. PWV je pri otrocih in mladostnikih zelo odvisen od telesne konstitucije.
Keywords:Metabolični sindrom, augmentacijski indeks, hitrost pulznih valov, otroci, bioimpedanca
Place of publishing:Maribor
Year of publishing:2017
PID:20.500.12556/DKUM-65225 New window
COBISS.SI-ID:6168127 New window
NUK URN:URN:SI:UM:DK:JC7B7ZPQ
Publication date in DKUM:29.11.2017
Views:1676
Downloads:172
Metadata:XML DC-XML DC-RDF
Categories:MF
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Secondary language

Language:English
Title:New mathods for metabolic syndrome risk evaluation in children
Abstract:Introduction: In the wake of epedemics of obesity and metabolic syndrome, we can expect the human heart and vessels to be exposed to even more pressures than we are witnessing at present. Early detection of persons who are prone to metabolic dysfunction and heart or vessel related diseases can offer an important contribution to preventive measures and the healing of diseases. Hypothesis: By measuring vessel function, body constitution and an accurate analysis of serum lipids we can discover the propensity to metabolic syndrome and heart diseases early in childhood, even before the appearance of clinical symptoms. Methods: The study featured 81 pupils aged 11-16. They completed a survey which gave us information about their social enviroment, eating habits and school success. Though analysis of the results of the Slofit programme we evaluated the body fitness of subjects. We measured body constitution, height, weight, waist circumference and hip circumference and upper arm skinfold and calculated the body mass index (BMI) and standard deviation according to the sex and age of the subjects (SDS BMI). Body compositon, the body fat percentage (FAT% ) was evaluated by bioimpedance. Charasteristics of the arterial system ware measured with an Arteriograph by determining the augmentation index (AIx), pulse wave velocity (PWV) and central systolic arterial pressure (SBPao). We analysed glucose (GLU) serum lipids along with free fatty acids (FFA) in samples of venous blood. Results: The augmentation index correlated as typically, with height, school success, some motoric tests and serum lipids. PWV showed significant correlation with body weight, height, BMI, SDS BMI, waist circumference, hip circumference, some motor tests and FFA. SBPao showed a negative correlation with school success. FAT% showed a significant correlation with GLU, FFA and other lipids. We detected very high values of AIx, SPBao and PWV in 5 pupils (6%). Conclusion: AIx, PWV, FFA and FAT% are good indicators of early vascular and metabolic disorders in children and adolescents. Increased AIx and SBPao are related to decreased school learning and motor abilities. PWV in children highly depends on body constitution.
Keywords:Metabolic syndrome, augmentation index, pulse vawe velocity, children, bioimpedance


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