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Title:Infliximab pri zdravljenju hudega na kortikosteroide neodzivnega zagona ulceroznega kolitisa - prikaz primera
Authors:ID Urlep Žužej, Darja (Author)
ID Dolinšek, Jernej (Author)
ID Mičetić-Turk, Dušanka (Author)
Files:.pdf Zdravniski_vestnik_2004_Urlep_Zuzej,_Dolinsek,_Micetic-Turk_Infliximab_pri_zdravljenju_hudega_na_kortikosteroide_neodzivnega_zagona_ulce.pdf (89,67 KB)
MD5: A31ED262F3F6D8A2EC5BD4F6327E6EA5
 
URL http://vestnik.szd.si/index.php/ZdravVest/article/view/2275
 
Language:Slovenian
Work type:Scientific work
Typology:1.04 - Professional Article
Organization:MF - Faculty of Medicine
Abstract:Izhodišča: Ulcerozni kolitis (UK) lahko poteka kot akutni zagon s hudo stopnjo vnetne dejavnosti, ki predstavlja življenje ogrožajoče stanje. Kortikosteroidi (KS) v intravenski obliki so zdravilo prve izbire za indukcijo klinične remisije pri akutnem hudem zagonu UK. Pri hudi obliki ulceroznega kolitisa, neodzivni na kortikosteroide, je potrebno kirurško zdravljenje. Bolniki in metode: Prikazan je primer desetletne deklice s hudo obliko na KS neodzivnega ulceroznega kolitisa. Da bi se izognili kirurškemu posegu, smo uvedli zdravljenje z infliximabom. Že po enkratni infuziji infliximaba je prišlo do hitrega izboljšanja kliničnega stanja in remisije bolezni, ki smo jo nato vzdrževali z azatioprinom. Zaključki: Zdravljenje z infliximabom je lahko uspešno pri hudo potekajočem, na KS neodzivnem UK. S tovrstnim zdravljenjem se lahko izognemo kirurškemu zdravljenju (kolektomiji), ki za bolnike predstavlja doživljenjsko invalidnost. Doseženo remisijo vzdržujemo z uveljavljenimi imunosupresivi (azatioprinom ali 6-merkaptopurinom).
Keywords:na kortikosteroide neodzivni ulcerozni kolitis, fulminantni potek, zdravljenje, infliximab
Publication status:Published
Publication version:Version of Record
Year of publishing:2004
Number of pages:str. 187-190
Numbering:Letn. 73, št. 4
PID:20.500.12556/DKUM-65270 New window
ISSN:1318-0347
UDC:616.3
ISSN on article:1318-0347
COBISS.SI-ID:1527615 New window
NUK URN:URN:SI:UM:DK:TE0FXER4
Publication date in DKUM:27.03.2017
Views:1754
Downloads:159
Metadata:XML DC-XML DC-RDF
Categories:Misc.
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Record is a part of a journal

Title:Zdravniški vestnik. glasilo Slovenskega zdravniškega društva
Publisher:Slovensko zdravniško društvo
ISSN:1318-0347
COBISS.SI-ID:32893696 New window

Licences

License:CC BY-NC 4.0, Creative Commons Attribution-NonCommercial 4.0 International
Link:http://creativecommons.org/licenses/by-nc/4.0/
Description:A creative commons license that bans commercial use, but the users don’t have to license their derivative works on the same terms.
Licensing start date:27.03.2017

Secondary language

Language:English
Title:Infliximab in the treatment of severe steroid-refractory ulcerative colitis - a case report
Abstract:Background: The natural course of ulcerative colitis (UC) can be complicated with an acute severe attack of high degree of activity of inflammation which represents a life-threatening condition. High-dose intravenous steroids have been the treatment of choice for induction of clinical remission of acute severe attack. In corticosteroid refractory ulcerative colitis a surgical therapy is required. Patients and methods: A case of a ten year-old girl with severe steroid-refractory UC is presented. The treatment with infliximab was introduced with intention to avoid colectomy. After the first infusion of infliximab her condition improved and clinical remission was achieved which was maintained with azathioprine. Conclusions: Therapy with infliximab can be successful for a severe steroid-refractory UC. The patients treated with infliximab can avoid surgical therapy (colectomy) which can represent a life-long disablement. The achieved remission is best maintained with conventional immunosuppressive therapy (azathioprine or 6-mercaptopurin).
Keywords:steroid-resistant ulcerative colitis, fulminant attack, therapy, infliximab


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