| Title: | Prognostic significance of uPA/PAI-1 level, HER2 status, and traditional histologic factors for survival in node-negative breast cancer patients |
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| Authors: | ID Fokter Dovnik, Nina (Author)
ID Takač, Iztok (Author) |
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| Files: |  Radiology_and_Oncology_2017_Dovnik,_Takac_Prognostic_significance_of_uPAPAI-1_level,_HER2_status,_and_traditional_histologic_factors_for.pdf (577,15 KB)
MD5: 1140BBE72E4FAF57632838893A39663C
 http://www.degruyter.com/view/j/raon.2017.51.issue-1/raon-2016-0024/raon-2016-0024.xml
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| Language: | English |
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| Work type: | Scientific work |
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| Typology: | 1.01 - Original Scientific Article |
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| Organization: | MF - Faculty of Medicine
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| Abstract: | Background: The association of HER2 status with urokinase plasminogen activator (uPA) and plasminogen activator inhibitor 1 (PAI-1) levels raises the question whether uPA/PAI-1 level carries additional clinically relevant prognostic information independently from HER2 status. The aim of our study was to compare the prognostic value of uPA/PAI-1 level, HER2 status, and traditional prognostic factors for survival in node-negative breast cancer patients.
Patients and methods: A retrospective analysis of 858 node-negative breast cancer patients treated in Maribor University Clinical Center, Slovenia, in the years 2000-2009 was performed. Data were obtained from patient medical records. The median follow-up time was 100 months. Univariate and multivariate analyses of disease-free (DFS) and overall survival (OS) were performed using the Cox regression and the Cox proportional hazards model.
Results: In univariate analysis, age, tumor size, grade, lymphovascular invasion, HER2 status and UPA/PAI-1 level were associated with DFS, and age, tumor size, grade, and uPA/PAI-1 level were associated with OS. In the multivariate model, the most important determinants of DFS were age, estrogen receptor status and uPA/PAI-1 level, and the most important factors for OS were patient age and tumor grade. The HR for death from any cause in the multivariate model was 1.98 (95% CI 0.83-4.76) for patients with high uPA and/or PAI-1 compared to patients with both values low.
Conclusions: uPA/PAI-1 level clearly carries an independent prognostic value regardless of HER2 status in node-negative breast cancer and could be used in addition to HER2 and other markers to guide clinical decisions in this setting. |
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| Keywords: | node-negative breast cancer, adjuvant systemic treatment, survival, uPA/PAI-1, HER2 status |
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| Publication status: | Published |
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| Publication version: | Version of Record |
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| Year of publishing: | 2017 |
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| Number of pages: | str. 65-73 |
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| Numbering: | Letn. 51, št. 1 |
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| PID: | 20.500.12556/DKUM-65612  |
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| ISSN: | 1581-3207 |
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| UDC: | 618.19-006 |
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| ISSN on article: | 1581-3207 |
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| COBISS.SI-ID: | 5717567 |
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| DOI: | 10.1515/raon-2016-0024 |
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| NUK URN: | URN:SI:UM:DK:3AHMOAMK |
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| Publication date in DKUM: | 10.05.2017 |
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| Views: | 1477 |
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| Downloads: | 472 |
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| Metadata: |    |
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| Categories: | Misc.
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