| Title: | L-arginine intake effect on adenin nucleotide metabolism in rat parenchymal and reproductive tissues |
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| Authors: | ID Kocić, Gordana (Author)
ID Nikolić, J. (Author)
ID Jevtović, Tatjana (Author)
ID Sokolović, Dušan (Author)
ID Kocić, H. (Author)
ID Cvetković, T. (Author)
ID Pavlović, Miloš (Author)
ID Cencič, Avrelija (Author)
ID Stojanovic, D. (Author) |
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| Files: |  The_Scientific_World_Journal_2012_Kocic_et_al._L-Arginine_Intake_Effect_on_Adenine_Nucleotide_Metabolism_in_Rat_Parenchymal_and_Reproduc.pdf (1,16 MB)
MD5: 5C89A1EBD310A88C6FFE706E7145EFFC
 http://www.hindawi.com/journals/tswj/2012/208239/
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| Language: | English |
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| Work type: | Scientific work |
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| Typology: | 1.01 - Original Scientific Article |
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| Organization: | MF - Faculty of Medicine
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| Abstract: | L-arginine is conditionally essential amino acid, required for normal cell growth, protein synthesis, ammonia detoxification, tissue growth and general performance, proposed in the treatment of men sterility and prevention of male impotence. The aim of the present paper was to estimate the activity of the enzymes of adenine nucleotide metabolismČ 5' -nucleotidase ( 5'-NU), adenosine deaminase (ADA), AMP deaminase, and xanthine oxidase (XO), during dietary intake of L-arginine for a period of four weeks of male Wistar rats. Adenosine concentration in tissues is maintained by the relative activities of the adenosine-producing enzyme, 5' -NU and the adenosine-degrading enzyme-ADA adenosine deaminase. Dietary L-arginine intake directed adenine nucleotide metabolism in liver, kidney, and testis tissue toward the activation of adenosine production, by increased 5' -NU activity and decreased ADA activity. Stimulation of adenosine accumulation could be of importance in mediating arginine antiatherosclerotic, vasoactive, immunomodulatory, and antioxidant effects. Assuming that the XO activity reflects the rate of purine catabolism in the cell, while the activity of AMP deaminase is of importance in ATP regeneration, reduced activity of XO, together with the increased AMP-deaminase activity, may suggest that adenine nucleotides are presumably directed to the ATP regenerating process during dietary L-arginine intake. |
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| Keywords: | biochemistry |
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| Publication status: | Published |
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| Publication version: | Version of Record |
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| Year of publishing: | 2012 |
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| Number of pages: | str. 1-4 |
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| Numbering: | Letn. 2012 |
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| PID: | 20.500.12556/DKUM-66223  |
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| ISSN: | 1537-744X |
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| UDC: | 577 |
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| ISSN on article: | 1537-744X |
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| COBISS.SI-ID: | 3355948 |
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| DOI: | 10.1100/2012/208239 |
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| NUK URN: | URN:SI:UM:DK:TUR5EPGM |
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| Publication date in DKUM: | 15.06.2017 |
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| Views: | 1196 |
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| Downloads: | 165 |
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| Metadata: |    |
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| Categories: | Misc.
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