| Title: | Haploinsufficiency for steroidogenic factor 1 affects maternal behavior in mice |
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| Authors: | ID Španić, Tanja (Author)
ID Grgurevič, Neža (Author)
ID Majdič, Gregor (Author) |
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| Files: |  Frontiers_in_behavioral_neuroscience_2016_Spanic,_Grgurevic,_Majdic_Haploinsufficiency_for_Steroidogenic_Factor_1_Affects_Maternal_Behav.pdf (477,98 KB)
MD5: 1A86042C9A081A0DE5A1FC4FE6278F78
PID: 20.500.12556/dkum/b086c2b1-30da-4bab-9198-2aa284a934a5
 http://journal.frontiersin.org/article/10.3389/fnbeh.2016.00131/full
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| Language: | English |
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| Work type: | Scientific work |
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| Typology: | 1.01 - Original Scientific Article |
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| Organization: | MF - Faculty of Medicine
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| Abstract: | Steroidogenic factor 1 (SF-1), officially designated NR5A1, is essential for gonadal and adrenal development and for the normal structure of the ventromedial hypothalamus (VMH), as demonstrated by SF-1 knockout mice (SF-1 KO), but much less is known about the possible effects of haploinsufficiency of the SF-1 gene. In the present study, maternal behavior in SF-1 KO heterozygous mice was evaluated. Behavioral tests revealed that SF-1 KO heterozygous females have impaired maternal behavior. In comparison to wild-type (WT) females, SF-1 KO heterozygous females retrieved significantly fewer pups into their nests, latency to retrieve and crouch over the pups was longer, and their nests were lower quality. As suggested by previous studies full dosage of SF-1 gene is needed for appropriate stress response and expression of brain-derived neurotrophic factor (BDNF) in the brain, and this might present a mechanism through which maternal behavior in SF-1 KO heterozygous females is impaired. |
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| Keywords: | mice, stress, steroidogenic factor 1, maternal behavior |
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| Publication status: | Published |
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| Publication version: | Version of Record |
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| Year of publishing: | 2016 |
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| Number of pages: | str. 1-5 |
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| Numbering: | Letn. 10 |
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| PID: | 20.500.12556/DKUM-66785  |
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| ISSN: | 1662-5153 |
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| UDC: | 612 |
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| ISSN on article: | 1662-5153 |
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| COBISS.SI-ID: | 4164474 |
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| DOI: | 10.3389/fnbeh.2016.00131 |
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| NUK URN: | URN:SI:UM:DK:3R05HJL9 |
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| Publication date in DKUM: | 10.07.2017 |
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| Views: | 1439 |
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| Downloads: | 417 |
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| Metadata: |    |
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| Categories: | Misc.
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