Funkcionalizacija površine silikonov s hitozanskimi nanodelci kot dostavnim sistemom za zdravilo : magistrsko delo

Jerenec, Urška

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Title:	Funkcionalizacija površine silikonov s hitozanskimi nanodelci kot dostavnim sistemom za zdravilo : magistrsko delo
Authors:	ID Jerenec, Urška (Author) ID Fras Zemljič, Lidija (Mentor) More about this mentor... ID Anžel, Ivan (Comentor) ID Rebol, Janez (Comentor)
Files:	MAG_Jerenec_Urska_2018.pdf (2,87 MB) MD5: 98C24841CFFFDD6E14668953DEA56378 PID: 20.500.12556/dkum/bdc44ef4-5218-4a1f-bae5-13f85b49531d
Language:	Slovenian
Work type:	Master's thesis/paper
Typology:	2.09 - Master's Thesis
Organization:	FS - Faculty of Mechanical Engineering
Abstract:	Silikoni so široko uporabni materiali. Med številnimi aplikacijami jih najdemo tudi kot sestavni del timpanalnih cevk, kjer je cilj napredek razvoja funkcionalnih površin cevk na način, ki izboljša procese zdravljenja vnetja ušes ter druga stanja ušesnih bolezni, kjer se uporabljajo te cevke. V magistrski nalogi smo se osredotočili na pripravo silikonskih površin z različnimi protimikrobnimi premazi. V našem primeru smo naredili premaze iz nanodelcev, kjer smo dodali amoksiklav, ali pa so bili nanodelci samo iz tripolifosfata in hitozana, katera lahko spontano tvorita nanodelce. Velikost delcev smo izmerili z metodo DLS, stabilnost disperzije smo preverili z meritvami Zeta potenciala, protimikrobnost smo testirali s pomočjo izbranih bakterij, fizikalno-kemijske lastnosti pa smo preverili z metodami UV-VIS, SEM, FT-IR in Franz celico. Pridobljeni rezultati kažejo, da so preliminarni poskusi na timpanalnih cevkah cevke s takšnim premazom odlična preventiva pred nastankom biofilma, omogočeno pa bi bilo tudi boljše celjenje (manjša možnost porasta bakterij zaradi protimikrobnega premaza). Amoksiklav je zaradi svoje široke uporabe in dostopnosti primerna izboljšava cevk. Za bolj gotove rezultate bi bilo potrebno opraviti še več ponovitev testiranj ter zamenjava amoksiklava s podobnim zdravilom, saj je amoksiklav zaradi svoje slabe stabilnosti precej problematičen za uporabo.
Keywords:	silikon, timpanalne cevke, hitozan, amoksiklav, nanodelci, plazemska aktivacija, DLS, Zeta potencial, UV-VIS, SEM, FT-IR, XPS, protimikrobnost, Franz celica
Place of publishing:	Maribor
Place of performance:	Maribor
Publisher:	[U. Jerenec]
Year of publishing:	2018
Number of pages:	XI, 85 f.
PID:	20.500.12556/DKUM-71674
UDC:	620.3(043.2)
COBISS.SI-ID:	22276630
NUK URN:	URN:SI:UM:DK:EVS5LY1W
Publication date in DKUM:	09.10.2018
Views:	1706
Downloads:	280
Metadata:
Categories:	KTFMB - FS
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Licences

License:	CC BY-NC-ND 4.0, Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International

Link:	http://creativecommons.org/licenses/by-nc-nd/4.0/
Description:	The most restrictive Creative Commons license. This only allows people to download and share the work for no commercial gain and for no other purposes.
Licensing start date:	27.08.2018

Secondary language

Language:	English
Title:	Functionalization of silicone surfaces with chitosan nanoparticles as the drug delivery system
Abstract:	Silicones are widely used materials which can also be used as part of tympanostomy tubes, where the goal is to further advance the functional surface of the tubes in a way that would enhance the healing processes of ear inflammations and other ear diseases where such tubes are used. The master’s thesis focuses on the treatment of silicone surfaces with various antimicrobial coatings. We prepared coatings made of nanoparticles and added amoxiclav, or, alternatively, the nanoparticles contained only triphosphate and chitosan which are both able to spontaneously form nanoparticles. The size of the particles was measured using the DLS method (dynamic light scattering), stability of the dispersion was checked with measurements of Zeta potential, antimicrobial properties were tested using selected bacteria, and physical and chemical properties were checked using the UV-VIS method (ultraviolet-visible spectroscopy), SEM method (scanning electron microscopy), FT-IR method (Fourier-transform infrared spectroscopy), and the Franz cell (in vitro release). The results show that preliminary tests with tympanostomy tubes with the selected coatings are excellent prevention against the occurrence of a biofilm, plus it enabled better healing (reduced likelihood of a growth of bacteria due to the antimicrobial coating). Due to its wide spectre of use and high accessibility, amoxiclav is a suitable addition to the tubes. In order to get more definitive results, we’d need repeat testings and amoxiclav should be replaced with a similar medicinal product since its use is relatively problematic due to its lack of stability.
Keywords:	silicone, tympanostomy tubes, chitosan, amoxiclav, nanoparticles, plasma activation, DLS, Zeta potential, UV-VIS, SEM, FT-IR, XPS, antimicrobial, Franz cell

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