Povezava komenzalne mikrobiomske RNA z razvojem nevrodegenerativnih bolezni

Tivadar, Stefanie

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Title:	Povezava komenzalne mikrobiomske RNA z razvojem nevrodegenerativnih bolezni
Authors:	ID Tivadar, Stefanie (Author) ID Drevenšek, Gorazd (Mentor) More about this mentor...
Files:	MAG_Tivadar_Stefanie_2019.pdf (7,65 MB) MD5: FC3D12CD16D18BEB3CFE928FC74BD0FB PID: 20.500.12556/dkum/408776e8-c341-4786-b9d6-98a4f014d340
Language:	Slovenian
Work type:	Master's thesis/paper
Typology:	2.09 - Master's Thesis
Organization:	FZV - Faculty of Health Sciences
Abstract:	Raziskave poročajo o pomembni povezavi med možgani in črevesjem ter o njuni povezanosti z nevrodegenerativnimi obolenji. Delovanje obeh je obojestransko in nenormalnosti na enem področju lahko privedejo do nevrodegenerativnih obolenj. K vzajemnemu sodelovanju prištevamo centralni živčni sistem, enterični živčni sistem, HPA os, vagus živec, mikrobioto, mikrobiomsko RNA in imunski sistem. Iz številnih raziskav lahko razberemo, da ima nenormalno delujoče črevesje s slabo mikrobioto, pomemben vpliv na nastanek plakov in posledično na razvoj nevrodegenerativnih obolenj. Za potencialno razumevanje celotnega delovanja se osredotočimo na komenzalne bakterije in komenzalno mikrobiomsko RNA, ki imajo pomembno vlogo pri uravnavanju metabolitov ter vplivajo na možgansko delovanje. Naloga zajame vrste RNA bakterij in ljudi. Po novih raziskavah lahko RNA gostitelja vstopi v bakterijo, kjer vpliva na uravnavanje bakterijskih transkriptov. Bakterijska RNA se lahko izloči prek veziklov in regulira črevesno homeostazo ter posledično vpliva na razvoj obolenj. Z mikroorganizmi vnešene RNA vplivajo tudi na metabolizem gostiteljevih RNA. Opisane so vrste nekodirajoče RNA in izpostavljena je circRNA kot potencialni biomarker. Nenormalno povečanje circRNA v črevesju, zaradi vnetij ali presežka bakterij, lahko vodi do obolenj. CircRNA lahko delujejo kot sporočilne molekule med celicami in imajo prenašalno vlogo, tako, da prenesejo informacije do sinaps. Zato lahko služijo kot pomemben del informacij, ki ima lahko terapevtske lastnosti za zdravljenje nevrodegenerativnih obolenj. CircRNA lahko služi kot potencialni diagnostični biomarker za številne bolezni. Za razumevanje celotne povezave mikrobiota – črevesje − možgani so potrebne še nadaljnje raziskave, saj so določene oblike mikrobiomske RNA šele v raziskovanju.
Keywords:	možgani, črevesje, mikrobiota, črevesno-možganska os, cirkularna RNA, centralni živčni sistem, mikrobiomska RNA.
Place of publishing:	Maribor
Publisher:	[S. Tivadar]
Year of publishing:	2019
PID:	20.500.12556/DKUM-73833
UDC:	577.113:612.33(043.2)
COBISS.SI-ID:	2520740
NUK URN:	URN:SI:UM:DK:6DWQTHCN
Publication date in DKUM:	16.09.2019
Views:	1344
Downloads:	187
Metadata:
Categories:	FZV
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Licences

License:	CC BY-ND 4.0, Creative Commons Attribution-NoDerivatives 4.0 International

Link:	http://creativecommons.org/licenses/by-nd/4.0/
Description:	Under the NoDerivatives Creative Commons license one can take a work released under this license and re-distribute it, but it cannot be shared with others in adapted form, and credit must be provided to the author.
Licensing start date:	19.06.2019

Secondary language

Language:	English
Title:	Connection of commensal microbiomic RNA with development of neurodegenerative diseases
Abstract:	Research reports important link between the brain, gut and their connection with neurodegenerative diseases. Both of them work mutual and side effects on one side can lead to neurodegenerative disorders. These includes central nervous system, enteric nervous system, HPA axis, vagus nerve, microbiota, microbiome RNA and immune system are included in the mutual cooperation. It can be seen from numerous studies that abnormally functioning gut with poor microbiota has a significant effect on plaque formation and consequently on the development of neurodegenerative diseases. For a potential understanding of overall function, we focus on commensal bacteria and commensal microbiome RNAs, which play an important role in regulating metabolites and affecting brain function. The task covers species of RNAs from bacteria and humans. According to new research, the host RNA may enter the bacterium where it affects bacterial transcriptional regulation. Bacterial RNA can be secreted via vesicles and regulate intestinal homeostasis and consequently affect the development of the disease. RNA-injected microorganisms also affect host RNA metabolism. Types of non-coding RNAs are described and circular RNA is highlighted as a potential biomarker. Abnormal increases in circular RNA in the gut due to inflammation or bacterial excess can lead to disease. Circular RNAs can act as messenger molecules between cells and play a transfer role by transmitting information to synapses. Therefore, they can serve as an important piece of information that may have therapeutic properties for the treatment of neurodegenerative disorders. Circular RNA can serve as a potential diagnostic biomarker for many diseases. Further research is needed to understand the overall microbiota-gut-brain connection, as certain forms of microbiome RNAs are still under research.
Keywords:	brain, gut, microbiote, gut-brain axis, circular RNA, central nervous system, microbiomic RNA.

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