| Title: | Numerical analysis of fluid flow in a vial : [master thesis] |
|---|
| Authors: | ID Časar, Žiga (Author)
ID Hriberšek, Matjaž (Mentor) More about this mentor... 
ID Zadravec, Matej (Comentor) |
|---|
| Files: |  MAG_Casar_Ziga_2019.pdf (2,66 MB)
MD5: 6BD3F418EBC728459BAFAF5F82B0CB36
PID: 20.500.12556/dkum/aaa2988b-2428-4364-ba0a-3d0bd895e6f5
|
|---|
| Language: | English |
|---|
| Work type: | Master's thesis/paper |
|---|
| Typology: | 2.09 - Master's Thesis |
|---|
| Organization: | FS - Faculty of Mechanical Engineering
|
|---|
| Abstract: | Lyophilization or freeze-drying is a widely used process in the pharmaceutical and food industry. In the process the solvent will be removed under extreme conditions of low temperature and low system pressures, whereby sublimation happens, the transition from the solid phase to the gas phase, with skipping the liquid phase, which happens bellow the triple point. This study focuses on numerical modeling at the start of the process, the so called primary drying. For this stage the highest mass flow rates of vapor are typical, since the driving force of the process is the pressure difference between the sublimation front and surrounding area. In this stage the non-bonded solvent is removed. Because of the extreme conditions the typical computational fluid dynamics approach is not suitable anymore and has to be corrected. One way to do this is to use additional models for fluid behavior at the solid wall. The study focuses on the influence of different boundary conditions on the solid wall, No-Slip, Free Slip and Maxwell Slip, and their effect on fluid flow inside the vial. A quantitative and qualitative comparison of the results is presented. |
|---|
| Keywords: | Lyophilization, Knudsen number, computational fluid dynamics, fluid flow, numerical modeling, slip boundary condition |
|---|
| Place of publishing: | Maribor |
|---|
| Place of performance: | Maribor |
|---|
| Publisher: | [Ž. Časar] |
|---|
| Year of publishing: | 2019 |
|---|
| Number of pages: | VIII, 34 str. |
|---|
| PID: | 20.500.12556/DKUM-73861 |
|---|
| UDC: | 004.414.23:57.086.13(043.2) |
|---|
| COBISS.SI-ID: | 22769686 |
|---|
| NUK URN: | URN:SI:UM:DK:DRN7IHG7 |
|---|
| Publication date in DKUM: | 09.07.2019 |
|---|
| Views: | 1770 |
|---|
| Downloads: | 224 |
|---|
| Metadata: |    |
|---|
| Categories: | KTFMB - FS
|
|---|
|
:
|
Copy citation |
|---|
| | | | Average score: | (0 votes) |
|---|
| Your score: | Voting is allowed only for logged in users. |
|---|
| Share: |  |
|---|
Hover the mouse pointer over a document title to show the abstract or click
on the title to get all document metadata. |
