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Title:Subklinična ateroskleroza pri bolnikih z recidivno-remitentno obliko multiple skleroze – pomen klasičnih dejavnikov tveganja, vnetja in genetskih polimorfizmov
Authors:ID Omerzu, Tomaž (Author)
ID Hojs Fabjan, Tanja (Mentor) More about this mentor... New window
ID Hojs, Radovan (Comentor)
ID Potočnik, Uroš (Comentor)
Files:.pdf DOK_Omerzu_Tomaz_2022.pdf (3,74 MB)
MD5: A179EED76F0BBD11AEA2BEC8E7088243
PID: 20.500.12556/dkum/6177170a-450c-49e8-9eaa-6adb46301e2b
 
Language:Slovenian
Work type:Doctoral dissertation
Typology:2.08 - Doctoral Dissertation
Organization:MF - Faculty of Medicine
Abstract:Multipla skleroza (MS) je kronična in vnetna bolezen osrednjega živčevja. Vnetje je prisotno v vseh stopnjah multiple skleroze in lahko povzroči dovzetnost za razvoj subklinične ateroskleroze. Ateroskleroza je zapleten proces z etiologijo, ki zajema več dejavnikov in vključuje vnetne, fibroproliferativne in angiogene odzive. Gre za kronični vnetni proces arterijske (žilne) stene in debelina karotidne intimne medije (IMT) velja za njen zgodnji označevalec. Namen te študije je bil primerjati subklinično aterosklerozo, vlogo vnetnih citokinov in pomen genetskih polimorfizmov med skupino bolnikov z recidivno-remitentno multiplo sklerozo (RR MS) in skupino zdravih posameznikov, ki so primerljivimi po starosti in spolu.
Keywords:multipla skleroza, ateroskleroza, debelina karotidne intime medije, cistatin C, intelevkin 6, genetski polimorfizmi
Place of publishing:Maribor
Year of publishing:2021
PID:20.500.12556/DKUM-79703 New window
COBISS.SI-ID:95591171 New window
Publication date in DKUM:31.01.2022
Views:1272
Downloads:159
Metadata:XML DC-XML DC-RDF
Categories:MF
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Licences

License:CC BY-NC-ND 4.0, Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International
Link:http://creativecommons.org/licenses/by-nc-nd/4.0/
Description:The most restrictive Creative Commons license. This only allows people to download and share the work for no commercial gain and for no other purposes.
Licensing start date:12.08.2021

Secondary language

Language:English
Title:SUBCLINICAL ATHEROSCLEROSIS IN PATIENTS WITH RELAPSING-REMITTING MULTIPLE SCLEROSIS – THE IMPORTANCE OF CLASSIC RISK FACTORS, INFLAMMATION AND GENETIC POLYMORPHISMS
Abstract:Multiple sclerosis (MS) is an inflammatory disorder of central nervous system. Inflammation is present in all stages of multiple sclerosis and may create high susceptibility to subclinical atherosclerosis. Atherosclerosis is a complicated process with multifactorial etiology and involves inflammatory, fibroproliferative and angiogenic responses. It is a chronic inflammatory process of the arterial wall and carotid intima-media thickness (IMT) is regarded as its early marker. The purpose of this study was to compare subclinical atherosclerosis, the role of inflammatory cytokines and the role of genetic polymorphisms between the group of patients with relapsing-remitting multiple sclerosis (RRMS) and healthy controls matched for age and sex.
Keywords:multiple sclerosis, atherosclerosis, carotid intima-media thickness, cystatin C, interleukin 6, genetic polymorphisms


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