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Title:Optimizacija procesa ekstrakcije farmacevtske učinkovine : magistrsko delo
Authors:ID Furek, Matej (Author)
ID Bogataj, Miloš (Mentor) More about this mentor... New window
ID Novak-Pintarič, Zorka (Comentor)
ID Pečelin, Peter (Comentor)
Files:.pdf MAG_Furek_Matej_2021.pdf (2,50 MB)
MD5: 025B75FE1E688863D8051ABF4DD0913E
PID: 20.500.12556/dkum/0bd8e098-4b51-4719-93be-2310706db92a
 
Language:Slovenian
Work type:Master's thesis/paper
Typology:2.09 - Master's Thesis
Organization:FKKT - Faculty of Chemistry and Chemical Engineering
Abstract:V magistrskem delu predstavljamo ekstrakcijo aktivne farmacevtske učinkovine iz vodne v organsko fazo z uporabo ekstrakcijsko-separacijskih centrifug. Izvedli smo simulacijo proizvodnega procesa ekstrakcije, ki je sestavljen iz šestih ekstrakcijsko-separacijskih centrifug (Westfalia). Simulacijo smo izvedli na osnovi podatkov, ki smo jih pridobili iz proizvodnje. Simulirali smo trenutno postavitev centrifug (1-1-1-1-1) ter izvedli simulacije štirih alternativnih postavitev centrifug. Rezultati nakazujejo, da se rezultati simulacije osnovne postavitve skladajo s podatki realnega procesa, na podlagi česar sklepamo, da so skladni tudi rezultati alternativnih postavitev. Na osnovi eksperimentalnega načrta smo razvili matematične modele za napovedovanje izkoristkov obravnavanih postavitev ekstrakcijsko-separacijskih centrifug. Polinomski matematični modeli za oceno učinkovitosti posamezne postavitve izkazujejo visoko ujemanje s podatki (R2 > 0,98). Razvite modele smo uporabili za optimizacijo procesa ekstrakcije. Rezultati optimizacije nakazujejo, da bi lahko z alternativno postavitvijo (2-1-1-1) dosegli enako učinkovitost, kar bi sicer zahtevalo 750 L/h višji pretok organskega topila, vendar bi s tem močno razbremenili centrifugi v prvi stopnji.
Keywords:ekstrakcijsko-separacijske centrifuge, aktivna farmacevtska učinkovina, simulacija, optimizacija
Place of publishing:Maribor
Place of performance:Maribor
Publisher:[M. Furek]
Year of publishing:2021
Number of pages:VII, 48 str.
PID:20.500.12556/DKUM-80383 New window
UDC:66.061.3.011(043.2)
COBISS.SI-ID:77466627 New window
Publication date in DKUM:22.09.2021
Views:1226
Downloads:125
Metadata:XML DC-XML DC-RDF
Categories:KTFMB - FKKT
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Licences

License:CC BY-NC-ND 4.0, Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International
Link:http://creativecommons.org/licenses/by-nc-nd/4.0/
Description:The most restrictive Creative Commons license. This only allows people to download and share the work for no commercial gain and for no other purposes.
Licensing start date:10.09.2021

Secondary language

Language:English
Title:Optimization of the pharmaceutical compound extraction process
Abstract:In the master thesis we present the extraction of active pharmaceutical ingredients from aqueous to organic phase using extraction-separation centrifuges. We have performed a simulation of the industrial extraction process, which comprises six extraction-separation centrifuges (Westfalia). The simulation was performed using Aspen Plus based on data from the production process. We simulated the currently installed centrifuge layout (1-1-1-1-1) and performed simulations of four alternative layouts. The results show that the simulation results of the current process layout are consistent with the results of the industrial installation. Therefore, we can conclude that the results of the alternative layouts are also consistent. We have developed mathematical models for predicting the extraction efficiency of the studied centrifuge layouts. The polynomial mathematical models for evaluating the efficiency of the individual layout exhibit high goodness-of-fit (R2 0.98). The models were used to optimize the extraction process. The optimization results indicate that the alternative centrifuge layout (2-1-1-1) centrifuge could be as efficient as the current one. This layout would require 750 L/h higher flow rate of organic solvent; however, the load on the centrifuges in the first stage would be greatly reduced.
Keywords:extraction-separation centrifuge, active pharmaceutical ingredient, simulation, optimization


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